Cancer chemotherapy is limited by significant inter-individual variations in responses and
toxicities. Such variations are often due to genetic alterations in drug metabolising enzymes …

Abstract With only 1.3− 4.3% in total hepatic CYP content, human CYP2D6 can metabolize
more than 160 drugs. It is a highly polymorphic enzyme and subject to marked inhibition by …

The metabolism of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in
humans. This polymorphism exhibits marked racial heterogeneity, with the poor metabolizer …

OBJECTIVES--To determine whether particular genotypes for the cytochrome P450 enzyme
CYP2D6, a polymorphic enzyme, are associated with susceptibility to ankylosing spondylitis …

Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic
pathways and are classified in various superfamilies. The CYP, or P450, superfamily …

The objective of this study was to investigate factors affecting steady‐state plasma
concentrations of thioridazine. A cross‐sectional study of patients receiving chronic …

Abstract Cytochrome P540 (CYP) 1A2 plays a role in the production of reactive oxygen
species (ROS), which have been implicated in the development of rheumatoid arthritis (RA) …

Objectives: To determine whether patients with idiopathic systemic lupus erythematosus
(SLE) are associated with impaired CYP2D6 activity and to gain insight into whether there is …

Background: Cardiovascular diseases are complex diseases that are influenced by both
environmental and genetic factors. CYP2D6 found in the brain and the heart is involved in …

Recent reports have shown association between CYP2D6 polymorphism and neuronal
degenerative diseases such as Parkinson's disease. We investigated the association …