[HTML][HTML] Future medicine: from molecular pathways to the collective intelligence of the body

E Lagasse, M Levin - Trends in Molecular Medicine, 2023 - cell.com
The remarkable anatomical homeostasis exhibited by complex living organisms suggests
that they are inherently reprogrammable information-processing systems that offer …

Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine

J Mathews, AJ Chang, L Devlin, M Levin - Patterns, 2023 - cell.com
Many aspects of health and disease are modeled using the abstraction of a" pathway"—a
set of protein or other subcellular activities with specified functional linkages between them …

[HTML][HTML] Morphoceuticals: Perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer and aging

L Pio-Lopez, M Levin - Drug Discovery Today, 2023 - Elsevier
Highlights•Growth, form and function of complex organs rely on dynamic morphogenesis.•
Morphoceuticals manipulate anatomical decision making by cellular collectives.• …

[HTML][HTML] How does the body know how old it is?

J Mitteldorf - Experimental Gerontology, 2023 - Elsevier
Based on the ideas of RA Fisher, neoDarwinism came to dominate evolutionary science in
the first half of the wentieth entury, and within that perspective aging could never be an …

Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain

S Manicka, VP Pai, M Levin - Iscience, 2023 - cell.com
Spatiotemporal patterns of cellular resting potential regulate several aspects of
development. One key aspect of the bioelectric code is that transcriptional and …

Aging as a morphostasis defect: a developmental bioelectricity perspective

L Pio-Lopez, M Levin - 2024 - osf.io
Maintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to
cancer and an accumulation of molecular and cellular disorders. We argue here that the …

Bioelectric Pharmacology of Cancer: A Systematic Review of Ion Channel Drugs Affecting the Cancer Phenotype

K Kofman, M Levin - Progress in Biophysics and Molecular Biology, 2024 - Elsevier
Cancer is a pernicious and pressing medical problem; moreover, it is a failure of
multicellular morphogenesis that sheds much light on evolutionary developmental biology …

Aging as a loss of morphostatic information: a developmental bioelectricity perspective

L Pio-Lopez, M Levin - Ageing Research Reviews, 2024 - Elsevier
Maintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to
cancer and an accumulation of molecular and cellular disorders. Perhaps, the most …

[HTML][HTML] Novel insights into the role of ion channels in cellular DNA damage response

K Maliszewska-Olejniczak, P Bednarczyk - Mutation Research/Reviews in …, 2024 - Elsevier
The DNA damage response (DDR) is a complex and highly regulated cellular process that
detects and repairs DNA damage. The integrity of the DNA molecule is crucial for the proper …

Electroceuticals: emerging applications beyond the nervous system and excitable tissues

S Balasubramanian, DA Weston, M Levin… - Trends in …, 2024 - cell.com
Electroceuticals have evolved beyond devices manipulating neuronal signaling for
symptomatic treatment, becoming more precise and disease modulating and expanding …