Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

Background The long-term efficacy and safety of time-restricted eating for weight loss are not
clear. Methods We randomly assigned 139 patients with obesity to time-restricted eating …

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain
poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22 …

Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus
type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to …

The interplay between diet, the gut microbiome, and host health is complex. Diets
associated with health have many similarities: high fiber, unsaturated fatty acids, and …

Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Intermittent fasting diets have become very popular in the past few years, as they can
produce clinically significant weight loss. These diets can be defined, in the simplest of …

Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake
restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the …

Over a quarter of the workforce in industrialized countries does shift work, which increases
the risk for cardiometabolic disease. Yet shift workers are often excluded from lifestyle …