Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …

Myelin, a lipid membrane that wraps axons, enabling fast neurotransmission and metabolic
support to axons, is conventionally thought of as a static structure that is set early in …

A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present …

Aging results in gray and white matter degeneration, but the specific microglial responses
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …

Myelin degeneration occurs in neurodegenerative diseases and aging. In these conditions,
resident oligodendrocyte progenitor cells (OPCs) differentiate into oligodendrocytes that …

Gene and protein expression data provide useful resources for understanding brain
function, but little is known about the lipid composition of the brain. Here, we perform …

BACKGROUND Myelin, produced by oligodendrocytes, supports the rapid and
synchronized transfer of information across the central nervous system (CNS). Earlier views …

Vincristine-induced peripheral neurotoxicity (VIPN) is a very common side effect of
vincristine chemotherapy among pediatric patients with cancer. Neuropathy may be sensory …

Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …

Hypomyelinating leukodystrophies constitute a subset of genetic white matter disorders
characterized by a primary lack of myelin deposition. Most patients with severe …