Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …

The goal of this review article is to assess how relevant is the concept of dissipative structure
for understanding the dynamical bases of non-equilibrium self-organization in biological …

Forward and backward transitions between epithelial and mesenchymal phenotypes play
crucial roles in embryonic development and tissue repair. Aberrantly regulated transitions …

The cancer stem cell (CSC) concept stands for undifferentiated tumor cells with the ability to
initiate heterogeneous tumors. It is also relevant in metastasis and can explain how …

Elucidating the design principles of regulatory networks driving cellular decisionmaking has
fundamental implications in mapping and eventually controlling cell-fate decisions. Despite …

Metastasis of carcinoma involves migration of tumor cells to distant organs and initiate
secondary tumors. Migration requires a complete or partial Epithelial-to-Mesenchymal …

Epithelial cells undergoing epithelial-to-mesenchymal transitions have often been shown to
behave as cancer stem cells, but the precise molecular connection remains elusive. At the …

Heterogeneous expression of the transcription factor NANOG has been linked to the
existence of various functional states in pluripotent stem cells. This heterogeneity seems to …

Failure of modularity remains a significant challenge for assembling synthetic gene circuits
with tested modules as they often do not function as expected. Competition over shared …

Phenotypic (non-genetic) heterogeneity has significant implications for the development and
evolution of organs, organisms, and populations. Recent observations in multiple cancers …