Ulcerative colitis (UC) and Crohn's disease (CD) are the major forms of idiopathic
inflammatory bowel disease (IBD). Both UC and CD are debilitating chronic disorders that …

Ulcerative colitis (UC) and Crohn's disease (CD) are debilitating idiopathic inflammatory
bowel diseases (IBDs) with symptoms that impair ability to function and quality of life. The …

Promising results have been reported with blood purification as adjuvant treatment;
however, the immunological mechanisms remain unclear. We have been developing a new …

4. Conclusion We have emphasized here the similarities that exist between the inflammatory
and regenerative responses in terms of mediators involved, providing evidence that liver …

Neutrophils play key roles in the inflammatory response. The IL-21 cytokine and receptor
system is known to be involved in various inflammatory diseases. However, the direct action …

Dysfunction of the innate immune system has been reported to cause intestinal
inflammation. Vitamin D 3 is known to be an important immune system regulator and exerts …

Objective. To assess the efficacy and safety of adsorptive granulocyte and monocyte
apheresis (GCAP) in patients with refractory rheumatoid arthritis (RA). Methods. Patients …

Background and aim Ulcerative colitis (UC) is characterized by repeated relapse and
remission. Because no fundamental therapeutic strategy has been established, the …

Objectives The management of alcoholic hepatitis remains controversial. Anti-tumour
necrosis factor treatments have been studied recently. We piloted the use of …

Pro‐inflammatory cytokines are involved in the pathogenesis of inflammatory skin diseases
attributable to activated neutrophils and macrophages. Myeloid‐derived suppressor cells …