Background—Ischemia in the placenta is considered the base of the pathogenesis of
preeclampsia, a pregnancy-specific syndrome in which soluble endoglin (sEng) is a …

In this review, we discuss the role of transforming growth factor-beta (TGF-β) in the
development of pulmonary vascular disease (PVD), both pulmonary arteriovenous …

Endoglin, a type I membrane glycoprotein expressed as a disulfide-linked homodimer on
human vascular endothelial cells, is a component of the transforming growth factor (TGF)-β …

The liver is perfused by both arterial and venous blood, with a resulting abnormal
microenvironment selecting for more-aggressive malignancies. Hepatocellular carcinoma …

Background The effects of novel biocompatible peritoneal dialysis (PD) solutions on human
peritoneal membrane pathology have yet to be determined. Quantitative evaluation of …

The understanding of renal fibrosis in chronic kidney disease (CKD) remains as a challenge.
More than 10% of the population of developed countries suffer from CKD. Proliferation and …

The circulatory system is walled off by different cell types, including vascular mural cells and
podocytes. The interaction and interplay between endothelial cells (ECs) and mural cells …

As nanotechnologies advance into clinical medicine, novel methods for applying
nanomedicine to cardiovascular diseases are emerging. Extensive research has been …

After endothelial injury, the transcription factor Krüppel-like factor 6 (KLF6) translocates into
the cell nucleus to regulate a variety of target genes involved in angiogenesis, vascular …

Preeclampsia (PE) is one of the leading causes of maternal morbidity and mortality
worldwide. This disease is believed to occur in two stages with placental dysfunction in early …