Fibrosis is a common phenomenon associated with several pathologies, characterized by
an excessive extracellular matrix deposition that leads to a progressive organ dysfunction …

Activin receptor-like kinase-1 or ALK-1 is a type I cell surface receptor for the transforming
growth factor-β (TGF-β) family of proteins. The role of ALK-1 in endothelial cells biology and …

Endoglin, alias CD105, is a human membrane glycoprotein highly expressed in vascular
endothelial cells. It is involved in angiogenesis and angiogenesis-related diseases …

Background The circulating form of human endoglin (sEng) is a cleavage product of
membrane-bound endoglin present on endothelial cells. Because sEng encompasses an …

Sarcomas are one of the most difficult type of cancer to manage and treat because of their
extremely heterogeneous molecular and morphological features. Despite the progress …

Cerebrovascular malformations comprise abnormal development of cerebral vasculature.
They can result in hemorrhagic stroke due to rupture of lesions as well as seizures and …

Endoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular
endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in …

Endoglin is a transforming growth factor β (TGF-β) coreceptor that serves as a prognostic,
diagnostic and therapeutic vascular target in human cancer. A number of endoglin …

Complex interactions between platelets and activated endothelium occur during the thrombo-
inflammatory reaction at sites of vascular injuries and during vascular hemostasis. The …

Diabetic nephropathy (DN) is a complication of diabetes mellitus that can lead to proteinuria
and a progressive decline in renal function. Endoglin, a co-receptor of TGF-β, is known …