Prevention and treatment of radiotherapy‐induced side effects

L Barazzuol, RP Coppes, P van Luijk - Molecular oncology, 2020 - Wiley Online Library
Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of
patients. The precision with which the radiation dose can be delivered is rapidly improving …

ICRP publication 118: ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs–threshold doses for tissue reactions in a …

FA Stewart, AV Akleyev, M Hauer-Jensen, JH Hendry… - Annals of the ICRP, 2012 - Elsevier
This report provides a review of early and late effects of radiation in normal tissues and
organs with respect to radiation protection. It was instigated following a recommendation in …

[HTML][HTML] Adverse effects of radiation therapy

H Majeed, V Gupta - 2020 - europepmc.org
Objectives: Review the pathophysiology and common side effects of radiation therapy.
Outline strategies for the treatment of radiotherapy side effects. Describe the importance of …

ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

A Brunelli, A Charloux, CT Bolliger… - European …, 2009 - Eur Respiratory Soc
A collaboration of multidisciplinary experts on the functional evaluation of lung cancer
patients has been facilitated by the European Respiratory Society (ERS) and the European …

Effects of radiation on normal tissue: consequences and mechanisms

HB Stone, CN Coleman, MS Anscher… - The lancet …, 2003 - thelancet.com
Acute radiation damage is most prominent in tissues with rapidly proliferating cells, such as
in epithelial surfaces of the skin or alimentary tract. Symptoms develop when functional cells …

American Society of Clinical Oncology clinical evidence review on the ongoing care of adult cancer survivors: cardiac and pulmonary late effects

JR Carver, CL Shapiro, A Ng, L Jacobs… - Journal of Clinical …, 2007 - ascopubs.org
Purpose To review the evidence on the incidence of long-term cardiac or pulmonary toxicity
secondary to chemotherapy, radiotherapy, or trastuzumab in symptomatic and asymptomatic …

TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?

M Martin, JL Lefaix, S Delanian - International Journal of Radiation …, 2000 - Elsevier
Radiation fibrosis is a frequent sequel of therapeutic or accidental radiation overexposure in
normal human tissues. One of the main fundamental problems yet unsolved in fibrotic …

Radiation pneumonitis

TJ Bledsoe, SK Nath… - Clinics in chest medicine, 2017 - chestmed.theclinics.com
Although radiation therapy provides the backbone of primary and adjuvant therapy for
several thoracic malignancies, the lungs have long been known to be exquisitely sensitive to …

Radiation pulmonary toxicity: from mechanisms to management

PR Graves, F Siddiqui, MS Anscher… - Seminars in radiation …, 2010 - Elsevier
The goal of radiation therapy is to reduce or eliminate tumor burden while sparing normal
tissues from long-term injury. Thoracic radiation presents a unique challenge because of the …

Molecular mechanisms and treatment of radiation-induced lung fibrosis

NH Ding, J Jian Li, LQ Sun - Current drug targets, 2013 - ingentaconnect.com
Radiation-induced lung fibrosis (RILF) is a severe side effect of radiotherapy in lung cancer
patients that presents as a progressive pulmonary injury combined with chronic …