The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

Renewed interest in the idea that cholinergic neurons of the central nervous system play an
important role in learning and/or memory has been stimulated by two key observations. First …

Scopolamine-treated normal young human subjects exhibit memory dysfunctions analogous
to those observed in demented patients. The dysfunctions are reversible by physostigmine …

The distribution of M1 and M2 muscarine receptors in the rat brain was investigated by in
vitro autoradiography. Muscarine receptors were visualized after complete receptor …

The autoradiographic distributions of receptors with high affinity for [3 H] oxotremorine-M
(the M2 receptor) and [3 H] pirenzepine (the M1 receptor) were studied in the rat brain. M1 …

The binding characteristics of N [3 H] methylscopolamine (3 H] NMS) to slide-mounted tissue
sections were studies using quantitative autoradiography. Binding of [3 H] NMS was …

The heterogeneity of muscarine receptors was examined in two brain regions (cerebral
cortex and cerebellum) and in some parasympathetically innervated peripheral tissues …

We recently demonstrated that the non-classical muscarinic receptor antagonist [3 H]
pirenzepine ([3 H] PZ) identifies a high affinity population of muscarinic sites in the rat …

AF-DX 116 (see chemical name below) is a competitive antagonist of muscarine receptors in
peripheral organs. In contrast to pirenzepine, its behaviour in functional experiments …

1 The selectivity profiles of the muscarinic receptor antagonists dicyclomine and
trihexyphenidyl have been examined in binding and functional studies and compared with …