MicroRNAs (miRNAs) are an emerging class of gene expression modulators with relevant
roles in several biological processes, including cell differentiation, development, apoptosis …

Breast cancer has become a leading cause of cancer-related deaths in women worldwide.
DNA methylation has been revealed to play an enormously important role in the …

Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders.
Understanding this diversity is essential to improving diagnosis and optimizing treatment …

Introduction MicroRNAs (miRNAs) are a group of small noncoding RNAs involved in the
regulation of gene expression. As such, they regulate a large number of cellular pathways …

Abstract Inflammatory Breast Cancer (IBC) is a highly aggressive malignancy with distinct
clinical and histopathological features whose molecular basis is unresolved. Here we …

Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …

To better understand the biology of hormone receptor–positive and–negative breast cancer
and to identify methylated gene markers of disease progression, we carried out a genome …

Polycomb repressive complex 2 (PRC2) and its core member enhancer of zeste homolog 2
(EZH2) mediate the epigenetic gene silencing mark: trimethylation of lysine 27 on histone 3 …

The ability of chromosome microarray analysis (CMA) to detect submicroscopic genetic
abnormalities has revolutionized the clinical diagnostic approach to individuals with …

Abstract Background Aberrant CpG island promoter DNA hypermethylation is frequently
observed in cancer and is believed to contribute to tumor progression by silencing the …