单克隆抗体药物以其特异性高, 亲和力强, 血清半衰期长等优点在肿瘤治疗领域得到广泛应用.
基于母体单克隆抗体而设计的双特异性抗体, 抗体片段, 抗体药物偶联物等将抗体类药物的开发 …

Purpose: The EGFR ligand, epiregulin (EREG), is highly expressed in colorectal cancers
(CRCs) and a biomarker for predicting benefit in RAS wildtype patients receiving EGFR …

Engineered cysteines are frequently used for site‐specific conjugation in antibody‐drug
conjugate (ADC) development. When cysteine‐engineered mAbs are produced in the cell …

The development of chemical methods for the site-selective modification of proteins have
been widely investigated for the past decades, especially in the therapeutic field. Because of …

[ES] La familia de receptores tirosina quinasa ErbB/HER y sus ligandos juegan un papel
fundamental en las vías de señalización implicadas en la proliferación, migración y …

Ex vivo tumor tissue cultures, such as organoids or explants, hold promise as a drug
screening platform for functional precision diagnostics. In this project, we have employed …

항체-약물복합체 (Antibody-drug Conjugate, ADC) 는 강력한 세포독성 항암제를 암세포
특이적인 항체에 접합하여 암세포 내부로 전달함으로써 정상세포 보다는 암세포에선택적인 …