Introduction: Despite recent advances in Alzheimer's disease (AD) research, no
breakthrough treatments have been discovered. Cholinesterase inhibitors and the NMDA …

Considerable clinical and epidemiological evidence links Alzheimer's disease (AD) and
depression. However, the molecular mechanisms underlying this connection are largely …

Objective The current study aims to examine the risk of suicide in persons diagnosed with
dementia during a hospitalization and its relationship to mood disorders. Design Event …

Depression is one of the most common psychiatric symptoms in Alzheimer's disease (AD),
and considerable evidence indicates that major depressive disorder increases the risk of …

It has been known for several decades that serotonergic neurotransmission is a key
regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of …

Along with cognitive decline, 90% of patients with dementia experience behavioral and
psychological symptoms of dementia, such as psychosis, aggression, agitation, and …

The evolution of sensory systems has let mammals develop complicated tactile end organs
to enable sophisticated sensory tasks, including social interaction, environmental …

The human 5-HT 6 receptor (5-HT 6 R) is one of the latest cloned receptors among the
known 5-HT receptors. Its abundant distribution in the limbic region, which participates in the …

Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by
irreversible cognitive declines. Senile plaques formed by amyloid-β (Aβ) peptides and …

J. Neurochem.(2012) 120 (Suppl. 1), 46–54. Abstract Alpha‐secretase‐mediated cleavage
of the amyloid precursor protein (APP) releases the neuroprotective APP fragment sαAPP …