We conducted a two-sample Mendelian randomization study to test the hypothesis that
raised plasma levels of the branched-chain amino acids isoleucine, leucine, and valine are …

Alzheimer's disease is a progressive neurodegenerative disease for which no cure exists.
There is a substantial need for new therapies that offer improved symptomatic benefit and …

Suicidal behavior is a common cause of death in the elderly and is often accompanied in
this population by disabilities and psychosocial impairment. Alzheimer's-related …

The monoaminergic systems are the target of several drugs for the treatment of mood, motor
and cognitive disorders as well as neurological conditions. In most cases, advances have …

The existence of a high co-morbidity between Alzheimer's disease (AD) and depression has
been known for a long time. More interesting though are recent studies indicating that …

The frontal cortex is a brain structure that plays an important role in cognition and is known
to be affected in Alzheimer's disease (AD) in humans. Over the past years, transgenic mouse …

Abstract The 5-HT 6 receptor (5-HT 6 R) is almost exclusively expressed in the brain and
has emerged as a promising target for cognitive disorders, including Alzheimer's disease. In …

Recordings made from layer V (L5) pyramidal cells of the prefrontal cortex (PFC) and
neocortex in rodent slice preparations have shown that serotonin (5-hydroxytryptamine, 5 …

Deterioration of the cortical cholinergic system is a leading neurochemical feature of
Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7 …

Drugs acting through 5-hydroxytryptamine (serotonin or 5-HT) systems modulate memory
and its alterations, although the mechanisms involved are poorly understood. 5-HT drugs …