Deterioration of the cortical cholinergic system is a leading neurochemical feature of
Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7 …

This review discussed the importance of mutated tau, amyloid and neuroinflammatory
factors and microglia in Alzheimer disease. In particular tau, CD4 and TNF alpha were …

Traditionally, the search for memory circuits has been focused on examinations of amnesic
and AD patients, cerebral lesions and neuroimaging. A complementary alternative has …

In order to determine whether short-(STM) and long-term memory (LTM) function in serial or
parallel manner, serotonin (5-hydroxtryptamine, 5-HT) receptor agonists were tested in …

The hippocampal region receives a dense serotoninergic innervation originating from both
medial and dorsal raphe nuclei. This innervation regulates hippocampal activity through the …

Since the development of chemical neuroanatomical tools in the 1960s, a tremendous
wealth of information has been generated on the anatomical components of the serotonergic …

Objective: Recent studies have suggested modifications of serotonin cerebral metabolism
and of 5-HT1A receptors density in Alzheimer disease (AD). This study aims at exploring …

Psychosis occurs across a wide variety of dementias with differing etiologies, including
Alzheimer's dementia, Parkinson's dementia, Lewy body dementia, frontotemporal …

BACKGROUND: Agitation is one of the most common neuropsychiatric symptoms of
Alzheimer's disease (AD), and is associated with serious adverse consequences for patients …

Background Symptomatic benefits have been reported for 5-HT 6 receptor antagonists in
Alzheimer's disease (AD) trials. SAM-760 is a potent and selective 5-HT 6 receptor …