About 60% to 70% of people with dementia have Alzheimer's Disease (AD), a neuro-
degenerative illness. One reason for this disorder is the misfolding of naturally occurring …

The use of dopamine receptor blockers for chronic singultus treatment is based—at least
partially—on circular thinking: chlorpromazine is FDA-approved for hiccups, chlorpromazine …

Abstract Serotonin or 5-hydroxytryptamine (5-HT) is primarily involved in the regulation of
learning and memory. Pathological changes in metabolism or functional imbalance of 5-HT …

Pomaglumetad methionil (LY2140023) is a mGlu2/3 receptor agonist prodrug reported in
2007 to possess antipsychotic efficacy based on results of a phase 2 trial conducted entirely …

Background and Purpose Many dementia patients exhibit behavioural and psychological
symptoms (BPSD) that include psychosis, aggressivity, depression and anxiety …

The 5-HT 6 R has been considered as an attractive therapeutic target in the brain due to its
exclusive expression in the brain. However, the mechanistic linkage between 5-HT 6 Rs and …

Serotonin (5-hydroxytryptamine, 5-HT) is well known to be closely associated with emotional
disorders, such as depression and schizophrenia. The seven main members of 5-HT …

Rationale Selective 5-ht 6 receptor antagonists like Ro 04-6790 prolong memory in many
rodent preclinical paradigms, possibly by blocking tonic 5-HT-evoked GABA release and …

The serotonin (5-HT) receptors of type 6 (5-HT6) are relatively new. They are quite different
from all other 5-HT receptors, as they are characterized by a short third cytoplasmatic loop …

A recent [18F] MPPF-positron emission tomography study has highlighted an
overexpression of 5-HT1A receptors in the hippocampus of patients with mild cognitive …