Mitophagy in cancer: a tale of adaptation

M Vara-Perez, B Felipe-Abrio, P Agostinis - Cells, 2019 - mdpi.com
In the past years, we have learnt that tumors co-evolve with their microenvironment, and that
the active interaction between cancer cells and stromal cells plays a pivotal role in cancer …

A comprehensive picture of extracellular vesicles and their contents. Molecular transfer to cancer cells

A Jurj, O Zanoaga, C Braicu, V Lazar, C Tomuleasa… - Cancers, 2020 - mdpi.com
Critical processes such as growth, invasion, and metastasis of cancer cells are sustained via
bidirectional cell-to-cell communication in tissue complex environments. Such …

Delineating the dynamic evolution from preneoplasia to invasive lung adenocarcinoma by integrating single-cell RNA sequencing and spatial transcriptomics

J Zhu, Y Fan, Y Xiong, W Wang, J Chen, Y Xia… - … & Molecular Medicine, 2022 - nature.com
The cell ecology and spatial niche implicated in the dynamic and sequential process of lung
adenocarcinoma (LUAD) from adenocarcinoma in situ (AIS) to minimally invasive …

Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy

F Barutta, S Bellini, S Kimura, K Hase, B Corbetta… - Autophagy, 2023 - Taylor & Francis
Podocyte injury leading to albuminuria is a characteristic feature of diabetic nephropathy
(DN). Hyperglycemia and advanced glycation end products (AGEs) are major determinants …

Metabolic tricks of cancer cells

K Hönigova, J Navratil, B Peltanova… - … et Biophysica Acta (BBA …, 2022 - Elsevier
One of the characteristics of cancer cells important for tumorigenesis is their metabolic
plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic …

Tunneling nanotubes and tumor microtubes in cancer

C Roehlecke, MHH Schmidt - Cancers, 2020 - mdpi.com
Intercellular communication among cancer cells and their microenvironment is crucial to
disease progression. The mechanisms by which communication occurs between distant …

Tunneling nanotubes, a novel mode of tumor cell–macrophage communication in tumor cell invasion

SJ Hanna, K McCoy-Simandle, E Leung… - Journal of cell …, 2019 - journals.biologists.com
The interaction between tumor cells and macrophages is crucial in promoting tumor invasion
and metastasis. In this study, we examined a novel mechanism of intercellular …

Movement of mitochondria with mutant DNA through extracellular vesicles helps cancer cells acquire chemoresistance

E Abad, A Lyakhovich - ChemMedChem, 2022 - Wiley Online Library
Triple negative breast cancer (TNBC) is one of the most aggressive subtypes of breast
cancer with the worst prognosis after chemo‐or radiation therapy. This is mainly due to the …

Tunneling nanotubes: The intercellular conduits contributing to cancer pathogenesis and its therapy

PK Melwani, BN Pandey - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Tunneling nanotubes (TNTs) are intercellular conduits, which meet the communication
needs of non-adjacent cells situated in the same tissue but at distances up to a few hundred …

Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects

N Matejka, J Reindl - Radiation Oncology, 2019 - Springer
Direct cell-to-cell communication is crucial for the survival of cells in stressful situations such
as during or after radiation exposure. This communication can lead to non-targeted effects …