[HTML][HTML] Periphery and brain, innate and adaptive immunity in Parkinson's disease

AS Harms, SA Ferreira, M Romero-Ramos - Acta neuropathologica, 2021 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a
central role in the death and dysfunction of neurons, both, in central, as well as in the …

The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options

Q Wang, Y Luo, K Ray Chaudhuri, R Reynolds, EK Tan… - Brain, 2021 - academic.oup.com
Parkinson's disease is a common neurodegenerative disorder in which gastrointestinal
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …

[HTML][HTML] The association between the gut microbiota and Parkinson's disease, a meta-analysis

T Shen, Y Yue, T He, C Huang, B Qu, W Lv… - Frontiers in aging …, 2021 - frontiersin.org
Parkinson's disease (PD) patients were often observed with gastrointestinal symptoms,
which preceded the onset of motor symptoms. Neuropathology of PD has also been found in …

[PDF][PDF] Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function

MM Alam, D Yang, XQ Li, J Liu, TC Back, A Trivett… - Cell reports, 2022 - cell.com
Alpha-synuclein (αS) is causally involved in the development of Parkinson disease (PD);
however, its role in normal vertebrate physiology has remained unknown. Recent studies …

[HTML][HTML] Central role of microglia in sepsis-associated encephalopathy: from mechanism to therapy

X Yan, K Yang, Q Xiao, R Hou, X Pan… - Frontiers in …, 2022 - frontiersin.org
Sepsis-associated encephalopathy (SAE) is a cognitive impairment associated with sepsis
that occurs in the absence of direct infection in the central nervous system or structural brain …

[HTML][HTML] The prion-like spreading of alpha-synuclein in parkinson's disease: Update on models and hypotheses

A Jan, NP Gonçalves, CB Vaegter, PH Jensen… - International journal of …, 2021 - mdpi.com
The pathological aggregation of the presynaptic protein α-synuclein (α-syn) and propagation
through synaptically coupled neuroanatomical tracts is increasingly thought to underlie the …

Parkinson's disease: a multisystem disorder

HN Costa, AR Esteves, N Empadinhas… - Neuroscience Bulletin, 2023 - Springer
The way sporadic Parkinson's disease (PD) is perceived has undergone drastic changes in
recent decades. For a long time, PD was considered a brain disease characterized by motor …

[HTML][HTML] Association between inflammatory bowel diseases and Parkinson's disease: systematic review and meta-analysis

Y Zhu, M Yuan, Y Liu, F Yang, WZ Chen… - Neural Regeneration …, 2022 - journals.lww.com
Growing evidence suggests that there are similar pathological mechanisms and closely
related pathogenic risk factors for inflammatory bowel disease (IBD) and Parkinson's …

[HTML][HTML] Rifaximin modifies gut microbiota and attenuates inflammation in Parkinson's disease: preclinical and clinical studies

CT Hong, L Chan, KY Chen, HH Lee, LK Huang… - Cells, 2022 - mdpi.com
Patients with Parkinson's disease (PD) exhibit distinct gut microbiota, which may promote
gut-derived inflammation. Rifaximin is a nonabsorbable antibiotic that can modify gut …

[HTML][HTML] Probiotics as functional foods: How probiotics can alleviate the symptoms of neurological disabilities

S Aghamohammad, A Hafezi, M Rohani - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Neurological disorders are diseases of the central nervous system with progressive loss of
nervous tissue. One of the most difficult problems associated with neurological disorders is …