Neuroinflammation is a critical factor in developing and progressing numerous brain
diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation …

Background Parkinson's disease (PD) is the second most common neurodegenerative
disease, and is characterized by accumulation of α-synuclein (α-syn). Neuroinflammation …

As a key regulator of the innate immune system, the NLRP3 inflammasome responds to a
variety of environmental insults through activation of caspase-1 and release of the …

Ischemic-induced neuronal injury arises due to low oxygen/nutrient levels and an
inflammatory response that exacerbates neuronal loss. NOD-like receptor family pyrin …

Activating inflammatory caspases and releasing pro-inflammatory mediators are two
essential functions of inflammasomes which are triggered in response to pathogen …

Abstract Wulfenioidones A− K (1–11) were abietane diterpenoids with highly oxidized 6/6/6
aromatic tricyclic skeleton isolated from the whole plant of Orthosiphon wulfenioides, and …

Background NLR family pyrin domain-containing 3 (NLRP3)-mediated pyroptosis plays a
key role in various acute and chronic inflammatory diseases. Targeted inhibition of NLRP3 …

Parkinson's disease (PD) is a common age-related neurodegenerative disorder
characterized by damage to nigrostriatal dopaminergic neurons. Key pathogenic …

Wulfenioidins A–C (1–3) with an unprecedented 6/5-5 tricyclic skeleton featuring the
unusual spiro [4.4] nonane were isolated from the whole plant of Orthosiphon wulfenioides …

We recently revealed a pivotal role of NLRP3 inflammasome in the neurotoxicity induced by
n-hexane, owing to its activation and release of pro-inflammatory cytokines. However, the …