Abstract The Morris Water Maze (MWM) was first established by neuroscientist Richard G.
Morris in 1981 in order to test hippocampal-dependent learning, including acquisition of …

Findings indicate that poor sleep is a risk factor for cognitive decline and Alzheimer's
disease. Although mechanisms underlying these associations are not yet clear, healthy …

To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …

The brain is highly dependent on an adequate delivery of oxygen and glucose from the
circulation, and cerebral blood flow (CBF) reductions impair neuronal function and, if …

Recent efforts have revealed that numerous protein-coding messenger RNAs have natural
antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a …

Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological
hallmark of Alzheimer's disease (AD). Aβ is generated from sequential cleavages of the β …

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

There is increasing evidence that cerebrovascular dysfunction plays a role not only in
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …

Alzheimer's disease (AD) is characterized by amyloid plaques composed of the β-amyloid
(Aβ) peptide surrounded by swollen presynaptic dystrophic neurites consisting of …

We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal
cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin …