Previous clinical studies have documented a close relationship between cerebrovascular
disease and risk of Alzheimer's disease. We examined possible mechanistic interactions …

The majority cases of Alzheimer's disease (AD) are sporadic late-onset form not being linked
to APP and PS1 gene mutations. It is believed that the environmental risk factors play an …

Alzheimer's disease (AD) and vascular dementia (VaD) are important causes of cognitive
decline in the elderly. As a result of an ageing population worldwide, the incidence of …

Alzheimer's disease (AD) and cerebrovascular diseases share common vascular risk factors
that have disastrous effects on cerebrovascular regulation. Endothelial cells, lining inner …

Importance Increasing evidence suggests that sleep-disordered breathing (SDB) increases
the risk of developing Alzheimer clinical syndrome. However, the brain mechanisms …

Rutin (quercetin-3-O-rutinoside) is a multifunctional natural flavonoid glycoside with
profound effects on the various cellular functions under pathological conditions. Due to the …

17β-Estradiol (estradiol or E2) is implicated as a neuroprotective factor in a variety of
neurodegenerative disorders. This review focuses on the mechanisms underlying E2 …

Amyloidogenicity and vascular dysfunction are the key players in the pathogenesis of
Alzheimer's disease (AD), involving dysregulated cellular interactions. An intricate balance …

Previous studies have shown a high prevalence of obstructive sleep apnea (OSA) among
patients with Alzheimer's disease (AD). However, it is poorly assessed whether chronic …

Summary γ-Secretase is composed of four proteins that are obligatory for protease activity:
presenilin, nicastrin, Aph1, and Pen-2. Despite the progress toward understanding the …