Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-
like cysteine-rich domain. This domain enables them to bind to Wnt ligands or frizzled (FzD) …

Secreted frizzled-related protein 1 (SFRP1) is a gene that belongs to the secreted
glycoprotein SFRP family. SFRP1 has been classified as a tumor suppressor gene due to …

Rhabdomyosarcoma (RMS) is a pediatric cancer with features of skeletal muscle; patients
with unresectable or metastatic RMS fare poorly due to high rates of disease recurrence …

Colorectal cancer (CRC) is one of the most common malignancies and is a major cause of
cancer-related deaths worldwide. Thus, there is a clinical need to improve early detection of …

The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin
signaling is frequently inactivated by promoter methylation and oncogenic activation of the …

Secreted frizzled-related protein 2 (SFRP2) is a glycoprotein with frizzled-like cysteine-rich
domain that binds with Wnt ligands or frizzled receptors to regulate Wnt signaling. SFRP2 is …

Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide, and late
stages (III-IV) in particular have low 5-year survival rates. Stage shifting by CRC screening …

Colorectal cancer (CRC) arises from accumulated genetic and epigenetic alterations, which
provide the possibility to identify tumor-specific biomarkers by analyzing fecal DNA …

Objective Gastric cancer patients generally have a poor outcome, particularly those with
advanced-stage disease which is defined by the increased invasion of cancer locally and is …

BACKGROUND Colon cancer is among the most commonly diagnosed cancers in the
United States with an estimated 97220 new cases expected by the end of 2018. It affects 1.2 …