[HTML][HTML] Refractory IgA Nephropathy: A Challenge for Future Nephrologists

V Di Leo, F Annese, F Papadia, MS Russo, M Giliberti… - Medicina, 2024 - mdpi.com
IgA nephropathy (IgAN) represents the most prevalent form of primary glomerulonephritis,
and, on a global scale, it ranks among the leading culprits behind end-stage kidney disease …

[HTML][HTML] Multiscale topology classifies cells in subcellular spatial transcriptomics

K Benjamin, A Bhandari, JD Kepple, R Qi, Z Shang… - Nature, 2024 - nature.com
Spatial transcriptomics measures in situ gene expression at millions of locations within a
tissue, hitherto with some trade-off between transcriptome depth, spatial resolution and …

Conjugated Nonionic Detergent Micelles: An Efficient Purification Platform for Dimeric Human Immunoglobulin A

TJ Withanage, M Lal, E Wachtel… - ACS Medicinal …, 2024 - ACS Publications
The SARS-COV-2 virus is a deadly agent of inflammatory respiratory disease. Since 2020,
studies have focused on developing new therapies based on galactose-rich IgA antibodies …

Unveiling biomarkers and therapeutic targets in IgA nephropathy through large-scale blood transcriptome analysis

T Gan, L Qu, S Qu, Y Qi, Y Zhang, Y Wang, Y Li… - International …, 2024 - Elsevier
Abstract Introduction IgA nephropathy (IgAN) is the most prevalent form of
glomerulonephritis. Unfortunately, molecular biomarkers for IgAN derived from omics studies …

Circulating Proteins and IgA Nephropathy

C Tang, P Chen, LL Xu, JC Lv, SF Shi… - Journal of the …, 2024 - journals.lww.com
Background: The therapeutic options for IgA nephropathy are rapidly evolving, but early
diagnosis and targeted treatment remain challenging. We aimed to identify circulating …

The predictive value of free thyroxine combined with tubular atrophy/interstitial fibrosis for poor prognosis in patients with IgA nephropathy

B Yang, W Zhou, L Cui, L Tian, Y Ni, M Yang… - Frontiers in …, 2024 - frontiersin.org
Background IgA nephropathy (IgAN), the most common type of glomerulonephritis, has great
individual differences in prognosis. Many studies showed the relationship between thyroid …

[HTML][HTML] Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis

Y Wang, H Wang, X Ma, Z Zhu, X Tian, R Fu, L Jia - BMC nephrology, 2024 - Springer
Background The objective of this study is to investigate the clinical and pathological
differences between patients with IgA nephropathy (IgAN) and IgA vasculitis associated …

[HTML][HTML] Exploring Novel Adverse Events of Nefecon

J Wang, Z Zhang, X Liu, S Shi, J Lv, Y Zhang… - Kidney International …, 2024 - Elsevier
Background Nefecon, the first innovative drug approved by both the US FDA and European
EMA for IgA nephropathy, lacked comprehensive real-world assessments of its adverse …

Comprehensive Druggable Genome-Wide Mendelian Randomization Reveals Therapeutic Targets for Kidney Diseases

Z Su, R Xue, W Liu, D Wu, L Wu, yuan Cheng, Q Wan - medRxiv, 2024 - medrxiv.org
Background: Kidney diseases, including membranous nephropathy (MN), IgA nephropathy
(IgAN), and chronic kidney disease (CKD), pose significant global health challenges due to …

[HTML][HTML] A Child With Concomitant Neuroblastoma and IgA Nephropathy: A Case Report and Literature Review

L Yu, J Wang, C Feng, G Huang, W Gu, J Xiong, J Mao - Cureus, 2024 - ncbi.nlm.nih.gov
Concurrent malignancy and IgA nephropathy are rare. Despite the lack of solid experimental
evidence, there are theoretical hypotheses of pathophysiology for the development of …