Oxidative damage to DNA has important implications for human health and has been
identified as a key factor in the onset and development of numerous diseases. Thus, it is …

Melatonin is an endogenous hormone derived from tryptophan that is mainly released from
the pineal gland in the dark. Melatonin regulates many biological functions such as sleep …

Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic
nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the …

Indole alkaloids are widely distributed in nature and have been particularly studied because
of their diverse biological activities, such as anti-inflammatory, anti-tumor, anti-bacterial, and …

The liver is composed of hepatocytes, cholangiocytes, Kupffer cells, sinusoidal endothelial
cells, hepatic stellate cells (HSCs) and dendritic cells; all these functional and interstitial …

Accumulation of aluminium (Al) in the brain is known to be a toxic insult that result in
neurodegenerative diseases and melatonin is known to have neuroprotective role. The …

In the therapeutic strategies, the role of diet is a well-established factor that can also have an
important role in liver diseases. Melatonin, identified in animals, has many antioxidant …

Alpinetin is an original medicinal plant flavonoid derived from Alpinia katsumadai and has
several biological activities. The current research aimed to evaluate the hepatoprotective …

The present study aimed to investigate the hepatoprotective effect of sesamol (SML), a
nutritional phenolic compound obtained from sesame seeds, in liver fibrosis induced by …

This study was aimed to investigate the potential ameliorative effects of omega-3 (ω3) fatty
acids against acrylamide (ACR)-induced neurotoxicity. Thirty-two adult male Sprague …