During the past 40 years, cytokines and cytokine receptors have been extensively
investigated as either cancer targets or cancer treatments. A strong preclinical rationale …

Ulcerative colitis (UC) specifically affects the colon and rectum through multifactorial
mechanisms associated with genetic alterations, environmental factors, microbiota, and …

Inflammatory bowel disease (IBD), as a representative inflammatory disease, currently has
multiple effective treatment options available and new therapeutic strategies are being …

As a main digestive organ and an important immune organ, the intestine plays a vital role in
resisting the invasion of potential pathogens into the body. Intestinal immune dysfunction …

Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases
(IBD) and have pathophysiological processes such as bowel necrosis and enteric neurons …

Abstract Interleukin-8 (CXCL8) produced in the tumor microenvironment correlates with poor
response to checkpoint inhibitors and is known to chemoattract and activate …

Background Damage to the healthy intestinal epithelial layer and regulation of the intestinal
immune system, closely interrelated, are considered pivotal parts of the curative treatment …

The gastrointestinal tract is an immunologically rich organ, containing complex cell networks
and dense lymphoid structures that safeguard this large absorptive barrier from pathogens …

Abstract Interleukin-6 (IL-6) is considered an inflammatory cytokine, which is involved not
only in most inflammatory states but it also plays a prominent role in inflammation associated …

Ulcerative colitis (UC) is a chronic inflammatory illness affecting the colon and rectum, with
current treatment methods being unable to meet the clinical needs of ulcerative colitis …