Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …
offer diagnostic information that is otherwise accessible conventionally through invasive …
[HTML][HTML] The emerging role of cell-free DNA as a molecular marker for cancer management
AJ Bronkhorst, V Ungerer, S Holdenrieder - Biomolecular detection and …, 2019 - Elsevier
An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
Origins, structures, and functions of circulating DNA in oncology
AR Thierry, S El Messaoudi, PB Gahan, P Anker… - Cancer and metastasis …, 2016 - Springer
While various clinical applications especially in oncology are now in progress such as
diagnosis, prognosis, therapy monitoring, or patient follow-up, the determination of structural …
diagnosis, prognosis, therapy monitoring, or patient follow-up, the determination of structural …
Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients
The analysis of tumor-derived circulating cell-free DNA opens up new possibilities for
performing liquid biopsies for the assessment of solid tumors. Although its clinical potential …
performing liquid biopsies for the assessment of solid tumors. Although its clinical potential …
The nexus of cfDNA and nuclease biology
DSC Han, YMD Lo - Trends in Genetics, 2021 - cell.com
Cell-free DNA (cfDNA) is a widely used noninvasive biomarker for diagnosis and prognosis
of multiple disease states. Emerging evidence suggests that cfDNA might not just be passive …
of multiple disease states. Emerging evidence suggests that cfDNA might not just be passive …
Enhanced detection of circulating tumor DNA by fragment size analysis
F Mouliere, D Chandrananda, AM Piskorz… - Science translational …, 2018 - science.org
Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on
genomic alterations but have rarely considered the biological properties of plasma cell-free …
genomic alterations but have rarely considered the biological properties of plasma cell-free …
Analysis of cell‐free DNA in maternal blood in screening for fetal aneuploidies: updated meta‐analysis
MM Gil, MS Quezada, R Revello… - … in obstetrics & …, 2015 - Wiley Online Library
Objective To review clinical validation or implementation studies of maternal blood cell‐free
(cf) DNA analysis and define the performance of screening for fetal trisomies 21, 18 and 13 …
(cf) DNA analysis and define the performance of screening for fetal trisomies 21, 18 and 13 …
New evidence that a large proportion of human blood plasma cell-free DNA is localized in exosomes
MR Fernando, C Jiang, GD Krzyzanowski, WL Ryan - PloS one, 2017 - journals.plos.org
Cell-free DNA (cfDNA) in blood is used as a source of genetic material for noninvasive
prenatal and cancer diagnostic assays in clinical practice. Recently we have started a …
prenatal and cancer diagnostic assays in clinical practice. Recently we have started a …
Blood-based liquid biopsies for prostate cancer: clinical opportunities and challenges
Liquid biopsy has been established as a powerful, minimally invasive, tool to detect clinically
actionable aberrations across numerous cancer types in real-time. With the development of …
actionable aberrations across numerous cancer types in real-time. With the development of …
The long and short of circulating cell-free DNA and the ins and outs of molecular diagnostics
P Jiang, YMD Lo - Trends in Genetics, 2016 - cell.com
The discovery of cell-free tumor and fetal DNA molecules in the plasma of cancer patients
and pregnant women, respectively, has opened up exciting opportunities in molecular …
and pregnant women, respectively, has opened up exciting opportunities in molecular …