Clinical proton MR spectroscopy in central nervous system disorders

G Öz, JR Alger, PB Barker, R Bartha, A Bizzi, C Boesch… - Radiology, 2014 - pubs.rsna.org
A large body of published work shows that proton (hydrogen 1 [1H]) magnetic resonance
(MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality …

The developing nervous system: a series of review articles: neurobiology of hypoxic-ischemic injury in the developing brain

MV Johnston, WH Trescher, A Ishida, W Nakajima… - Pediatric …, 2001 - nature.com
Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although
systemic and cerebrovascular physiologic factors play an important role in the initial phases …

Neonatal encephalopathy: an inadequate term for hypoxic–ischemic encephalopathy

JJ Volpe - Annals of neurology, 2012 - Wiley Online Library
Abstract This Point of View article addresses neonatal encephalopathy (NE) presumably
caused by hypoxia–ischemia and the terminology currently in wide use for this disorder. The …

The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial

D Azzopardi, P Brocklehurst, D Edwards, H Halliday… - BMC pediatrics, 2008 - Springer
Background A hypoxic-ischaemic insult occurring around the time of birth may result in an
encephalopathic state characterised by the need for resuscitation at birth, neurological …

MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy

AJ Barkovich, SP Miller, A Bartha… - American Journal …, 2006 - Am Soc Neuroradiology
BACKGROUND: Although the imaging, spectroscopic, and diffusion characteristics of brains
of infants with neonatal encephalopathy have been described, the time course during which …

Hypoxic–ischemic brain injury in the term infant-current concepts

L Shalak, JM Perlman - Early human development, 2004 - Elsevier
An enhanced understanding of the cellular characteristics contributing to ongoing brain
injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted …

Topical review: Long-term developmental outcome of asphyxiated term neonates

ME Dilenge, A Majnemer… - Journal of child …, 2001 - journals.sagepub.com
Asphyxia remains one of the main causes of later disability in term infants. Despite many
publications identifying possible predictors of outcome in this population of interest, little is …

Predictive value of fetal scalp blood lactate concentration and pH as markers of neurologic disability

K Kruger, B Hallberg, M Blennow, M Kublickas… - American journal of …, 1999 - Elsevier
Objectives: We aimed to analyze the predictive value of the fetal scalp blood lactate
concentration and pH, especially in regard to outcome variables that are strong predictors of …

Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates

AJ Barkovich, K Baranski, D Vigneron… - American journal …, 1999 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Neurologic and developmental outcomes of asphyxiated,
term neonates are difficult to predict applying clinical or laboratory criteria. In this study, we …

Oxidative metabolism, apoptosis and perinatal brain injury

DL Taylor, AD Edwards, H Mehmet - Brain Pathology, 1999 - Wiley Online Library
Perinatal hypoxic‐ischaemic injury (HII) is a significant cause of neurodevelopmental
impairment and disability. Studies employing 31P magnetic resonance spectroscopy to …