Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Perivascular inflammation is a prominent pathologic feature in most animal models of
pulmonary hypertension (PH) as well as in pulmonary arterial hypertension (PAH) patients …

Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary
hypertension (PH). However, the mechanisms by which biophysical properties of the …

Twenty years ago, Rho-kinase was identified as an important downstream effector of the
small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important …

Pulmonary arterial hypertension (PAH) is a progressive vascular disease with a high
mortality rate. It is characterized by an occlusive vascular remodeling due to a pro …

Background: An emerging metabolic theory of pulmonary hypertension (PH) suggests that
cellular and mitochondrial metabolic dysfunction underlies the pathology of this disease. We …

The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …

Background—The mechanisms of right ventricular (RV) failure in pulmonary arterial
hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have …

Pulmonary arterial hypertension (PAH) remains a mysterious killer that, like cancer, is
characterized by tremendous complexity. PAH development occurs under sustained and …

Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary dysfunctional disease,
characterized by progressive vascular remodeling. Inflammation is an increasingly …