Oxidative stress: The nexus of obesity and cognitive dysfunction in diabetes

H Li, J Ren, Y Li, Q Wu, J Wei - Frontiers in Endocrinology, 2023 - frontiersin.org
Obesity has been associated with oxidative stress. Obese patients are at increased risk for
diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative …

Status of metabolomic measurement for insights in Alzheimer's disease progression—What is missing?

C Yin, AC Harms, T Hankemeier, A Kindt… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is an aging-related neurodegenerative disease, leading to the
progressive loss of memory and other cognitive functions. As there is still no cure for AD, the …

Cord blood lipid correlation network profiles are associated with subsequent attention-deficit/hyperactivity disorder and autism spectrum disorder symptoms at 2 years …

K Vacy, S Thomson, A Moore, A Eisner, S Tanner… - …, 2024 - thelancet.com
Background Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder
(ASD) are neurodevelopmental conditions with early life origins. Alterations in blood lipids …

Metabolic profiling of Alzheimer's disease: Untargeted metabolomics analysis of plasma samples

T Milos, D Rojo, GN Erjavec, M Konjevod… - Progress in Neuro …, 2023 - Elsevier
Alzheimer's disease (AD) is often not recognized or is diagnosed very late, which
significantly reduces the effectiveness of available pharmacological treatments …

Danggui-Shaoyao-San Attenuates Cognitive Impairment via the Microbiota–Gut–Brain Axis With Regulation of Lipid Metabolism in Scopolamine-Induced Amnesia

P Liu, X Zhou, H Zhang, R Wang, X Wu, W Jian… - Frontiers in …, 2022 - frontiersin.org
Danggui-Shaoyao-San (DSS) has a long history of being used as a traditional medicine
(TCM) and has been reported to show therapeutic effects in alleviating the symptoms of …

Fecal 16S rRNA sequencing and multi-compartment metabolomics revealed gut microbiota and metabolites interactions in APP/PS1 mice

X Cheng, Y Tan, H Li, J Huang, D Zhao, Z Zhang… - Computers in Biology …, 2022 - Elsevier
Background Alzheimer's disease is a significant public health issue. Recent studies have
shown that the gut microbiota plays a vital role in the onset and development of Alzheimer's …

Diabetes mellitus and energy dysmetabolism in Alzheimer's disease: understanding the relationships and potential therapeutic targets

AY Onaolapo, FO Ojo, OO Adeleye… - Current Diabetes …, 2023 - ingentaconnect.com
Over the last century, there has been a gradual but sustained increase in life expectancy
globally. A consequence of increased life expectancy is an associated rise in the prevalence …

Epigenomics and lipidomics integration in Alzheimer disease: pathways involved in early stages

C Peña-Bautista, L Álvarez-Sánchez… - Biomedicines, 2021 - mdpi.com
Background: Alzheimer Disease (AD) is the most prevalent dementia. However, the
physiopathological mechanisms involved in its development are unclear. In this sense, a …

Six genetically linked mutations in the CD36 gene significantly delay the onset of Alzheimer's disease

O Šerý, T Zeman, K Sheardová, M Vyhnálek… - Scientific Reports, 2022 - nature.com
The risk of Alzheimer's disease (AD) has a strong genetic component, also in the case of late-
onset AD (LOAD). Attempts to sequence whole genome in large populations of subjects …

Fundamental neurochemistry review: Old brain stories‐Influence of age and sex on the neurodegeneration‐associated lipid changes

L Cuenca‐Bermejo, A Prinetti… - Journal of …, 2023 - Wiley Online Library
Brain aging is a naturally occurring process resulting in the decline of cognitive functions
and increased vulnerability to develop age‐associated disorders. Fluctuation in lipid species …