PGC1α: friend or foe in cancer?

F Mastropasqua, G Girolimetti, M Shoshan - Genes, 2018 - mdpi.com
The PGC1 family (Peroxisome proliferator-activated receptor γ (PPARγ) coactivators) of
transcriptional coactivators are considered master regulators of mitochondrial biogenesis …

Mitochondria participate in chemoresistance to cisplatin in human ovarian cancer cells

LX Zampieri, D Grasso, C Bouzin, D Brusa… - Molecular Cancer …, 2020 - AACR
Ovarian cancer is an aggressive disease that affects about 300,000 patients worldwide, with
a yearly death count of about 185,000. Following surgery, treatment involves adjuvant or …

Mitochondria in oral cancer stem cells: Unraveling the potential drug targets for new and old drugs

I Olmedo, D Martínez, J Carrasco-Rojas, JA Jara - Life Sciences, 2023 - Elsevier
Head and neck cancer is a major health problem worldwide, with most cases arising in the
oral cavity. Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer …

Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer

A Nath, PA Cosgrove, H Mirsafian, EL Christie… - Nature …, 2021 - nature.com
The evolution of resistance in high-grade serous ovarian cancer (HGSOC) cells following
chemotherapy is only partially understood. To understand the selection of factors driving …

Anticancer activity of broccoli, its organosulfur and polyphenolic compounds

A Gasmi, A Gasmi Benahmed, M Shanaida… - Critical Reviews in …, 2023 - Taylor & Francis
The use of natural bioactive constituents from various food sources for anticancer purposes
has become increasingly popular worldwide. Broccoli (Brassica oleracea var. italica) is on …

Methods to evaluate changes in mitochondrial structure and function in cancer

BP Rickard, M Overchuk, VA Chappell, M Kemal Ruhi… - Cancers, 2023 - mdpi.com
Simple Summary Mitochondria, which play crucial roles in energy production and in
maintaining cellular homeostasis, are potential therapeutic targets in a variety of diseases …

[HTML][HTML] Cancer stem cells, epithelial-mesenchymal transition, ATP and their roles in drug resistance in cancer

H Zhang, A Steed, M Co, X Chen - Cancer Drug Resistance, 2021 - ncbi.nlm.nih.gov
The cancer stem cell (CSC) state and epithelial-mesenchymal transition (EMT) activation are
tightly interconnected. Cancer cells that acquire the EMT/CSC phenotype are equipped with …

Mitochondria-centric bioenergetic characteristics in cancer stem-like cells

MK Shin, JH Cheong - Archives of pharmacal research, 2019 - Springer
Metabolic and genotoxic stresses that arise during tumor progression and anti-cancer
treatment, respectively, can impose a selective pressure to promote cancer evolution in the …

CRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α

X Fu, Q Zhang, Z Wang, Y Xu, Q Dong - Cell Death & Disease, 2024 - nature.com
Ovarian cancer is the most lethal malignancy among gynecologic cancers, and primary and
secondary chemotherapy resistance is one of the important reasons for poor prognosis of …

Metabolic reprogramming of the tumor immune microenvironment in ovarian cancer: A novel orientation for immunotherapy

Y Lin, X Zhou, Y Ni, X Zhao, X Liang - Frontiers in Immunology, 2022 - frontiersin.org
Ovarian cancer is the most lethal gynecologic tumor, with the highest mortality rate.
Numerous studies have been conducted on the treatment of ovarian cancer in the hopes of …