Background: Glycosylation is one of the most fundamental post-translational modifications.
Importantly, glycosylation is altered in many cancers. These alterations have been proven to …

Glioblastoma (GBM) is uniformly fatal with a 1-year median survival, despite best available
treatment, including radiotherapy (RT). Impacts of prior RT on tumor recurrence are poorly …

Platinum-based chemotherapy is the cornerstone treatment for female high-grade serous
ovarian carcinoma (HGSOC), but choosing an appropriate treatment for patients hinges on …

Metabolic reprogramming at a cellular level contributes to many diseases including cancer,
yet few assays are capable of measuring metabolic pathway usage by individual cells within …

With the onset of resistance, ovarian cancer cells display almost unpredictable adaptive
potential. This may derive from the tumor genetic ancestry and can be additionally tailored …

One of the most significant therapeutic challenges in the treatment of ovarian cancer is the
development of recurrent platinum-resistant disease. Cancer stem cells (CSCs) are …

Ovarian Cancer is the fifth most common cancer in females and remains the most lethal
gynecological malignancy as most patients are diagnosed at late stages of the disease …

Background Maximal effort cytoreductive surgery is associated with improved outcomes in
advanced high-grade serous ovarian cancer (HGSOC). However, despite complete gross …

Background Deregulated metabolism is a hallmark of cancer and recent evidence
underlines that targeting tumor energetics may improve therapy response and patient …

Chemotherapy such as cisplatin is widely used to treat ovarian cancer either before or after
surgical debulking. However, cancer relapse due to chemotherapy resistance is a major …