Polycyclic aromatic hydrocarbons (PAHs) are a family of toxicants that are ubiquitous in the
environment. These contaminants generate considerable interest, because some of them …

Cancers of the colon are most common in the Western world. In majority of these cases,
there is no familial history and sporadic gene damage seems to play an important role in the …

The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

Since the demonstration of the multistage nature of carcinogenesis in experimental work on
mouse skin carcinogenesis (and subsequently on various other organ systems in other …

Therapeutic agents, active substances as well as metabolites, have been detected in the
environment, notably in the aquatic compartment. Such contamination may induce adverse …

The sequence of events involved in maintenance of homeostasis must encompass
mechanisms within single cells as well as interactions between cells within a population. To …

It is becoming increasingly apparent that genetic factors are inadequate to fully explain
many processes that shape development and disease. For example, monozygotic twin pairs …

Sediment extracts from three polluted sites of the river Elbe basin were fractionated using a
novel online fractionation procedure. Resulting fractions were screened for mutagenic, aryl …

The following is a position paper challenging the paradigm that 'carcinogen= mutagen', and
that the current rodent bioassay to predict risks to human cancers is relevant and useful …

Polycyclic aromatic hydrocarbons (PAHs) are a broad class of ubiquitous environmental
pollutants with known or suspected carcinogenic properties. Tumor promotion is a cell …