Bringing precision to the understanding and treatment of mental disorders requires
instruments for studying clinically relevant individual differences. One promising approach is …

The persistence of drug taking despite its adverse consequences plays a central role in the
presentation, diagnosis, and impacts of addiction. Eventual recognition and appraisal of …

The nervous system is a product of evolution. That is, it was constructed through a long
series of modifications, within the strong constraints of heredity, and continuously subjected …

Deep brain stimulation (DBS) is an invasive approach to precise modulation of
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …

Making effective decisions during approach-avoidance conflict is critical in daily life.
Aberrant decision-making during approach-avoidance conflict is evident in a range of …

Fear and anxiety are adaptive emotions that serve important defensive functions, yet in
excess, they can be debilitating and lead to poor mental health. Computational modelling of …

Regret describes recognizing alternative actions could have led to better outcomes. It
remains unclear whether regret derives from generalized mistake appraisal or instead …

Inhibition can be defined as a phenomenon in which an agent prevents or suppresses a
behavioral state that would otherwise occur. Associative learning studies have extensively …

Abstract Theory-driven and data-driven computational approaches to psychiatry have
enormous potential for elucidating mechanism of disease and providing translational …

Background Stress is a major risk factor for depression, and both are associated with
important changes in decision-making patterns. However, decades of research have only …