[HTML][HTML] Interleukin-6 interweaves the bone marrow microenvironment, bone loss, and multiple myeloma
The immune system is strongly linked to the maintenance of healthy bone. Inflammatory
cytokines, specifically, are crucial to skeletal homeostasis and any dysregulation can result …
cytokines, specifically, are crucial to skeletal homeostasis and any dysregulation can result …
[HTML][HTML] The role of hydrogen peroxide in redox-dependent signaling: homeostatic and pathological responses in mammalian cells
N Di Marzo, E Chisci, R Giovannoni - Cells, 2018 - mdpi.com
Hydrogen peroxide (H2O2) is an important metabolite involved in most of the redox
metabolism reactions and processes of the cells. H2O2 is recognized as one of the main …
metabolism reactions and processes of the cells. H2O2 is recognized as one of the main …
[HTML][HTML] The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling
Vascular endothelial cells (ECs) form a critical interface between blood and tissues that
maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in …
maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in …
[HTML][HTML] ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression
N Li, Q Liu, Y Han, S Pei, B Cheng, J Xu, X Miao… - Nature …, 2022 - nature.com
Chronic inflammation and an immunosuppressive microenvironment promote prostate
cancer (PCa) progression and diminish the response to immune checkpoint blockade (ICB) …
cancer (PCa) progression and diminish the response to immune checkpoint blockade (ICB) …
[HTML][HTML] Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling
Recent evidence from cancer research indicates that lactate exerts a suppressive effect on
innate immune responses in cancer. This study investigated the mechanisms by which …
innate immune responses in cancer. This study investigated the mechanisms by which …
[HTML][HTML] Targeting SARS-CoV-2 proteases for COVID-19 antiviral development
The emergence of severe acute respiratory syndrome (SARS-CoV-2) in 2019 marked the
third occurrence of a highly pathogenic coronavirus in the human population since 2003. As …
third occurrence of a highly pathogenic coronavirus in the human population since 2003. As …
Molecular basis of NF-κB signaling
J Napetschnig, H Wu - Annual review of biophysics, 2013 - annualreviews.org
NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …
and inflammatory processes in response to both injury and infection. In the latent state, NF …
[HTML][HTML] Skin-on-a-chip model simulating inflammation, edema and drug-based treatment
Recent advances in microfluidic cell cultures enable the construction of in vitro human skin
models that can be used for drug toxicity testing, disease study. However, current in vitro …
models that can be used for drug toxicity testing, disease study. However, current in vitro …
Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β‐Cell Dysfunction
The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …
Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach
S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …
biological activity via binding to a promoter region in the nucleus and transcribing various …