Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies;
however, patients can experience cardiotoxic effects and this has limited the use of this …

Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

Heart disease is the leading cause of death worldwide. A key pathogenic factor in the
development of lethal heart failure is loss of terminally differentiated cardiomyocytes …

Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat
various cancers. The serious adverse effects of DOX on cardiotoxicity limit its clinical …

Oxidative stress and cardiomyocyte apoptosis play critical roles in doxorubicin (DOX)-
induced cardiotoxicity. Previous studies indicated that fibronectin type III domain-containing …

Ferroptosis is a new form of regulated cell death (RCD) driven by iron-dependent lipid
peroxidation, which is morphologically and mechanistically distinct from other forms of RCD …

Doxorubicin is utilized for anti-neoplastic treatment for several decades. The utility of this
drug is limited due to its side effects. Generally, doxorubicin toxicity is originated from the …

Doxorubicin (DOX) is the most widely used anthracycline anticancer agent; however, its
cardiotoxicity limits its clinical efficacy. Numerous studies have elucidated the mechanisms …

Anthracyclines are the cornerstone of many chemotherapy regimens for a variety of cancers.
Unfortunately, their use is limited by a cumulative dose-dependent cardiotoxicity. Despite …

Background Doxorubicin, an anthracycline chemotherapeutic agent, is widely used in the
treatment of many cancers. However, doxorubicin posts a great risk of adverse …