Digital endpoints in clinical trials of Alzheimer's disease and other neurodegenerative diseases: challenges and opportunities

AK Brem, S Kuruppu, C de Boer, M Muurling… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) and other neurodegenerative diseases such as Parkinson's
disease (PD) and Huntington's disease (HD) are associated with progressive cognitive …

An overview of the ADReSS-M Signal Processing Grand Challenge on Multilingual Alzheimer's Dementia Recognition through Spontaneous Speech

S Luz, F Haider, D Fromm, I Lazarou… - IEEE Open Journal …, 2024 - ieeexplore.ieee.org
The ADReSS-M Signal Processing Grand Challenge was held at the 2023 IEEE
International Conference on Acoustics, Speech and Signal Processing, ICASSP 2023. The …

Automation of language sample analysis

H Liu, B MacWhinney, D Fromm, A Lanzi - Journal of Speech, Language, and …, 2023 - ASHA
Purpose: A major barrier to the wider use of language sample analysis (LSA) is the fact that
transcription is very time intensive. Methods that can reduce the required time and effort …

The Optimization of a Natural Language Processing Approach for the Automatic Detection of Alzheimer's Disease Using GPT Embeddings

BS Runde, A Alapati, NG Bazan - Brain Sciences, 2024 - mdpi.com
The development of noninvasive and cost-effective methods of detecting Alzheimer's
disease (AD) is essential for its early prevention and mitigation. We optimize the detection of …

[HTML][HTML] Text Dialogue Analysis for Primary Screening of Mild Cognitive Impairment: Development and Validation Study

C Wang, S Liu, A Li, J Liu - Journal of Medical Internet Research, 2023 - jmir.org
Background Artificial intelligence models tailored to diagnose cognitive impairment have
shown excellent results. However, it is unclear whether large linguistic models can rival …

A Survey on Using Linguistic Markers for Diagnosing Neuropsychiatric Disorders with Artificial Intelligence

IR Zaman, S Trausan-Matu - Information, 2024 - mdpi.com
Neuropsychiatric disorders affect the lives of individuals from cognitive, emotional, and
behavioral aspects, impact the quality of their lives, and even lead to death. Outside the …

Multimodal deep learning for dementia classification using text and audio

K Lin, PY Washington - Scientific Reports, 2024 - nature.com
Dementia is a progressive neurological disorder that affects the daily lives of older adults,
impacting their verbal communication and cognitive function. Early diagnosis is important to …

GPT-4 and Neurologists in Screening for Mild Cognitive Impairment in the Elderly: A Comparative Analysis Study

H Yang, R Wang, C Wang, hui guo, H Cai, F Zhang… - medRxiv, 2023 - medrxiv.org
This study evaluates the efficacy of GPT-4 in screening for Mild Cognitive Impairment (MCI)
in the elderly, comparing it with junior neurologists. MCI is a precursor to dementia …

[HTML][HTML] Natural language processing-driven framework for the early detection of language and cognitive decline

K Panesar, MBPC de Alba - Language and Health, 2023 - Elsevier
Abstract Natural Language Processing (NLP) technology has the potential to provide a non-
invasive, cost-effective method using a timely intervention for detecting early-stage language …

Optimizing and Evaluating Pre-Trained Large Language Models for Alzheimer's Disease Detection

F Casu, E Grosso, A Lagorio… - 2024 32nd Euromicro …, 2024 - ieeexplore.ieee.org
This research focuses on developing improved diagnostic tools for Alzheimer's Disease
(AD), a condition impacting approximately 50 million individuals globally. In the paper, we …