Metabolomics helps identify metabolites to characterize/refine perturbations of biological
pathways in living organisms. Pre-analytical, analytical, and post-analytical limitations that …

The deficiency of fibrinogen, prothrombin, factor V (FV), FVII, FVIII, FIX, FX, FXI, and FXIII,
called rare coagulation disorders (RCDs), may result in coagulopathies leading to …

Glanzmann thrombasthenia (GT) is a rare inherited autosomal recessive bleeding disorder
of platelet function caused by a quantitative or qualitative defect of platelet membrane …

Over 110 million units of blood are collected yearly. The need for blood products is greater in
developing countries, but so is the risk of contracting a transfusion-transmitted infection …

Abstract Aims Untargeted Metabolomics is a “hypothesis-generating discovery strategy” that
compares groups of samples (eg, cases vs controls); identifies the metabolome and …

The few approved disinfection techniques for blood derivatives promote damage in the
blood components, representing risks for the transfusion receptor. Antimicrobial …

Blood transfusions are vital components of modern medical treatment to which there is no
viable alternative despite efforts to create artificial blood. Each year thousands of lives are …

The emergence of a novel class of infectious agent composed exclusively of a misfolded
protein (termed prions) has been a challenge in modern biomedicine. Despite similarities on …

Hemophilia is an inherited bleeding disorder that mainly affects males. Globally, there are
about 400 000 people with hemophilia and only 25% of them receive adequate treatment …

The regulatory process is currently designed to ensure drug safety during the pre-marketing
process. Due to limitations of the pivotal studies owing to their short duration and small …