Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder
MH Cho, BD Hobbs, EK Silverman - The Lancet Respiratory …, 2022 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease.
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …
[HTML][HTML] Surfactant protein D in respiratory and non-respiratory diseases
GL Sorensen - Frontiers in medicine, 2018 - frontiersin.org
Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
Lessons from ECLIPSE: a review of COPD biomarkers
The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points
(ECLIPSE) study was a large 3-year observational controlled multicentre international study …
(ECLIPSE) study was a large 3-year observational controlled multicentre international study …
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease
Rationale: A genome-wide association study (GWAS) for circulating chronic obstructive
pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker …
pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker …
[HTML][HTML] Pathways to disease from natural variations in human cytoplasmic tRNAs
Perfectly accurate translation of mRNA into protein is not a prerequisite for life. Resulting
from errors in protein synthesis, mistranslation occurs in all cells, including human cells. The …
from errors in protein synthesis, mistranslation occurs in all cells, including human cells. The …
Updates on the COPD gene list
Y Bossé - International journal of chronic obstructive pulmonary …, 2012 - Taylor & Francis
A genetic contribution to develop chronic obstructive pulmonary disease (COPD) is well
established. However, the specific genes responsible for enhanced risk or host differences …
established. However, the specific genes responsible for enhanced risk or host differences …
Timing during translation matters: synonymous mutations in human pathologies influence protein folding and function
R Rauscher, Z Ignatova - Biochemical Society Transactions, 2018 - portlandpress.com
Ribosomes translate mRNAs with non-uniform speed. Translation velocity patterns are a
conserved feature of mRNA and have evolved to fine-tune protein folding, expression and …
conserved feature of mRNA and have evolved to fine-tune protein folding, expression and …
[HTML][HTML] Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury
P Silveyra, J Floros - Frontiers in bioscience: a journal and virtual …, 2012 - ncbi.nlm.nih.gov
Pulmonary surfactant, a lipoprotein complex, maintains alveolar integrity and plays an
important role in lung host defense, and control of inflammation. Altered inflammatory …
important role in lung host defense, and control of inflammation. Altered inflammatory …