The emerging field of oncolytic virus-based cancer immunotherapy

R Ma, Z Li, EA Chiocca, MA Caligiuri, J Yu - Trends in cancer, 2023 - cell.com
Oncolytic viruses (OVs) provide novel and promising therapeutic options for patients with
cancers resistant to traditional therapies. Natural or genetically modified OVs are …

The sodium/iodide symporter (NIS): molecular physiology and preclinical and clinical applications

S Ravera, A Reyna-Neyra, G Ferrandino… - Annual review of …, 2017 - annualreviews.org
Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …

The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics

T Kogai, GA Brent - Pharmacology & therapeutics, 2012 - Elsevier
Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in
thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β …

[HTML][HTML] Novel therapeutics in radioactive iodine-resistant thyroid cancer

T Fullmer, ME Cabanillas, M Zafereo - Frontiers in Endocrinology, 2021 - frontiersin.org
Iodine-resistant cancers account for the vast majority of thyroid related mortality and, until
recently, there were limited therapeutic options. However, over the last decade our …

Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets

C Spitzweg, KC Bible, LC Hofbauer… - The lancet Diabetes & …, 2014 - thelancet.com
Approximately 30% of patients with advanced, metastatic differentiated thyroid cancer have
radioiodine-refractory disease, based on decreased expression of the sodium iodide …

[HTML][HTML] The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment

C Spitzweg, PJ Nelson, E Wagner… - Endocrine-related …, 2021 - erc.bioscientifica.com
Cloning of the sodium iodide symporter (NIS) 25 years ago has opened an exciting chapter
in molecular thyroidology with the characterization of NIS as one of the most powerful …

Selective detection of iodide and cyanide anions using gold-nanoparticle-based fluorescent probes

SC Wei, PH Hsu, YF Lee, YW Lin… - ACS Applied Materials & …, 2012 - ACS Publications
We developed two simple, rapid, and cost-effective fluorescent nanosensors, both featuring
bovine serum albumin labeled with fluorescein isothiocyanate (FITC))-capped gold …

A review of species differences in the control of, and response to, chemical-induced thyroid hormone perturbations leading to thyroid cancer

JR Foster, H Tinwell, S Melching-Kollmuss - Archives of Toxicology, 2021 - Springer
This review summarises the current state of knowledge regarding the physiology and control
of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and …

The sodium iodide symporter (NIS) as an imaging reporter for gene, viral, and cell-based therapies

AR Penheiter, SJ Russell, SK Carlson - Current gene therapy, 2012 - ingentaconnect.com
Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-
invasive imaging of reporter gene products to reveal the distribution of molecular …

[HTML][HTML] Fluoride exposure induces inhibition of sodium/iodide symporter (NIS) contributing to impaired iodine absorption and iodine deficiency: molecular …

DT Waugh - International Journal of Environmental Research and …, 2019 - mdpi.com
The sodium iodide symporter (NIS) is the plasma membrane glycoprotein that mediates
active iodide transport in the thyroid and other tissues, such as the salivary, gastric mucosa …