The emerging field of oncolytic virus-based cancer immunotherapy
Oncolytic viruses (OVs) provide novel and promising therapeutic options for patients with
cancers resistant to traditional therapies. Natural or genetically modified OVs are …
cancers resistant to traditional therapies. Natural or genetically modified OVs are …
The sodium/iodide symporter (NIS): molecular physiology and preclinical and clinical applications
S Ravera, A Reyna-Neyra, G Ferrandino… - Annual review of …, 2017 - annualreviews.org
Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …
The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics
T Kogai, GA Brent - Pharmacology & therapeutics, 2012 - Elsevier
Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in
thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β …
thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β …
[HTML][HTML] Novel therapeutics in radioactive iodine-resistant thyroid cancer
T Fullmer, ME Cabanillas, M Zafereo - Frontiers in Endocrinology, 2021 - frontiersin.org
Iodine-resistant cancers account for the vast majority of thyroid related mortality and, until
recently, there were limited therapeutic options. However, over the last decade our …
recently, there were limited therapeutic options. However, over the last decade our …
Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets
C Spitzweg, KC Bible, LC Hofbauer… - The lancet Diabetes & …, 2014 - thelancet.com
Approximately 30% of patients with advanced, metastatic differentiated thyroid cancer have
radioiodine-refractory disease, based on decreased expression of the sodium iodide …
radioiodine-refractory disease, based on decreased expression of the sodium iodide …
[HTML][HTML] The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment
Cloning of the sodium iodide symporter (NIS) 25 years ago has opened an exciting chapter
in molecular thyroidology with the characterization of NIS as one of the most powerful …
in molecular thyroidology with the characterization of NIS as one of the most powerful …
Selective detection of iodide and cyanide anions using gold-nanoparticle-based fluorescent probes
We developed two simple, rapid, and cost-effective fluorescent nanosensors, both featuring
bovine serum albumin labeled with fluorescein isothiocyanate (FITC))-capped gold …
bovine serum albumin labeled with fluorescein isothiocyanate (FITC))-capped gold …
A review of species differences in the control of, and response to, chemical-induced thyroid hormone perturbations leading to thyroid cancer
JR Foster, H Tinwell, S Melching-Kollmuss - Archives of Toxicology, 2021 - Springer
This review summarises the current state of knowledge regarding the physiology and control
of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and …
of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and …
The sodium iodide symporter (NIS) as an imaging reporter for gene, viral, and cell-based therapies
AR Penheiter, SJ Russell, SK Carlson - Current gene therapy, 2012 - ingentaconnect.com
Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-
invasive imaging of reporter gene products to reveal the distribution of molecular …
invasive imaging of reporter gene products to reveal the distribution of molecular …
[HTML][HTML] Fluoride exposure induces inhibition of sodium/iodide symporter (NIS) contributing to impaired iodine absorption and iodine deficiency: molecular …
DT Waugh - International Journal of Environmental Research and …, 2019 - mdpi.com
The sodium iodide symporter (NIS) is the plasma membrane glycoprotein that mediates
active iodide transport in the thyroid and other tissues, such as the salivary, gastric mucosa …
active iodide transport in the thyroid and other tissues, such as the salivary, gastric mucosa …