CD8+ T cells are critical to combat pathogens and eradicate malignantly transformed cells.
To exert their effector function and kill target cells, T cells produce copious amounts of …

Background Recent discoveries have revealed that fibronectin type III domain containing 3B
(FNDC3B) acts as an oncogene in various cancers; however, its role in glioma remains …

Toll-like receptors (TLR) belong to the pattern recognition receptors (PRR). TLR7 and the
closely correlated TLR8 affiliate with toll-like receptors family, are located in endosomes …

Emerging evidence in clinical and preclinical studies indicates that success of
immunotherapies can be impacted by the state of the microbiome. Understanding the role of …

Resident memory T (TRM) cells have been recently established as an important subset of
memory T cells that provide early and essential protection against reinfection in the absence …

Colorectal cancer (CRC) accounts for approximately 10% of all cancer cases worldwide.
Conventional treatment has relied on chemotherapy, radiation therapy and surgery with …

Memory CD8+ T cells are indispensable for maintaining long‐term immunity against
intracellular pathogens and tumors. Despite their presence at oxygen‐deprived infected …

A key feature of immune cells, such as T cells, is their rapid responsiveness to activation.
The response rate of T cells depends on the signal strength, and the type of signals they …

Innate and adaptive immunity synergistically contribute to an effective anti-tumor response.
Therapeutics targeting T cells, such as immune checkpoint inhibitors and engineered …

A recent article in Proceedings of the National Academy of Sciences investigated γδ T cell
antigen specificity in mice and humans, in which the authors show that γδ T cell antigen …