Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

Polymyxins are polycationic antimicrobial peptides that are currently the last-resort
antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections. The …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

Polymyxins have recently been re-introduced into the therapeutic arsenal to combat
infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence …

Pseudomonas aeruginosa is intrinsically resistant to a variety of antimicrobials and can
develop resistance during anti-pseudomonal chemotherapy both of which compromise …

While the misuse of antibiotics has clearly contributed to the emergence and proliferation of
resistant bacterial pathogens, with major health consequences, it remains less clear if the …

Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Colistin resistance is rare in Acinetobacter baumannii, and little is known about its
mechanism. We investigated the role of PmrCAB in this trait, using (i) resistant and …

The ability of gram-negative bacteria to resist killing by antimicrobial agents and to avoid
detection by host immune systems often entails modification to the lipopolysaccharide (LPS) …

Pseudomonas aeruginosa can develop resistance to polymyxin and other cationic
antimicrobial peptides. Previous work has shown that mutations in the PmrAB and PhoPQ …