Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity

X Hua, D Wang - Journal of hazardous materials, 2023 - Elsevier
The antioxidant 6-PPD has been widely used to prevent cracking and thermal oxidative
degradation and to extend the service life of tire rubber. 6-PPD quinone (6-PPDQ) is formed …

Polyethylene nanoplastics cause reproductive toxicity associated with activation of both estrogenic hormone receptor NHR-14 and DNA damage checkpoints in C …

Z Liu, X Hua, Y Zhao, Q Bian, D Wang - Science of The Total Environment, 2024 - Elsevier
As the most commercial polymer, the polyethylene nanoparticle (PE-NP) has been
discharged into the environment and poses potential risks to organisms. However, the …

Disruption of dopamine metabolism by exposure to 6-PPD quinone in Caenorhabditis elegans

X Hua, D Wang - Environmental Pollution, 2023 - Elsevier
Caenorhabditis elegans is a useful model for examining metabolic processes and related
mechanisms. We here examined the effect of exposure to N-(1, 3-dimethylbutyl)-N′-phenyl …

Comparison of reproductive toxicity between pristine and aged polylactic acid microplastics in Caenorhabditis elegans

Y Shao, X Hua, Y Li, D Wang - Journal of Hazardous Materials, 2024 - Elsevier
Caenorhabditis elegans was employed as model to compare reproductive toxicity between
pristine and aged polylactic acid microplastics (PLA-MPs). Aged PLA-MPs induced by UV …

Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans

X Hua, D Wang - Science of The Total Environment, 2024 - Elsevier
The exposure risk of 6-PPD quinone (6-PPDQ) has aroused increasing concern. In the
natural environment, 6-PPDQ could interact with other pollutants, posing more severe …

Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics

W He, J Chao, A Gu, D Wang - Science of the Total Environment, 2024 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ), a
transformation product of tyre-derived 6-PPD, has been frequently detected in different …

[HTML][HTML] Polystyrene nanoparticles strengthen high glucose toxicity associated with alteration in insulin signaling pathway in C. elegans

Z Zhuang, T Liu, Z Liu, D Wang - Ecotoxicology and Environmental Safety, 2024 - Elsevier
Using Caenorhabditis elegans as animal model, we investigated the effect of exposure to
polystyrene nanoparticles (PS-NPs) in the range of μg/L on high glucose toxicity induction …

Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Z Liu, Q Bian, D Wang - Journal of Hazardous Materials, 2024 - Elsevier
Abstract Exposure to N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-
PPDQ) caused toxicity on Caenorhabditis elegans, including reproductive toxicity. However …

Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans

Y Wang, G Liang, J Chao, D Wang - Science of the Total Environment, 2024 - Elsevier
As the derivatives of p-phenylenediamines (PPDs), PPD quinones (PPDQs) have received
increasing attention due to their possible exposure risk. We compared the intestinal toxicity …

Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and …

L Zhang, Y Wang, D Wang - Archives of Pharmacal Research, 2023 - Springer
Paeoniflorin is the major active compound of total glycoside of paeony in Paeonia lactiflora
Pall. Although several aspects of beneficial effects of paeoniflorin have been described …