Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations

D Primorac, V Molnar, E Rod, Ž Jeleč, F Čukelj… - Genes, 2020 - mdpi.com
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Cartilage tissue engineering: From proinflammatory and anti‑inflammatory cytokines to osteoarthritis treatments

S Liu, Z Deng, K Chen, S Jian… - Molecular …, 2022 - spandidos-publications.com
Osteoarthritis (OA), one of the most common joint diseases, is characterized by fibrosis,
rhagadia, ulcers and attrition of articular cartilage due to a number of factors. The etiology of …

Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences

S Lopa, A Colombini, M Moretti… - Knee surgery, sports …, 2019 - Springer
Purpose Osteoarthritis (OA) represents a relevant social and economic burden worldwide.“
Mesenchymal stem cells” or, as recently proposed,“medicinal signaling cells”(MSCs) have …

Pathophysiological perspective of osteoarthritis

MHM Yunus, A Nordin, H Kamal - Medicina, 2020 - mdpi.com
Osteoarthritis (OA) is the most well-known degenerative disease among the geriatric and is
a main cause of significant disability in daily living. It has a multifactorial etiology and is …

[HTML][HTML] NLRP3 as a potentially novel biomarker for the management of osteoarthritis

MJ McAllister, M Chemaly, AJ Eakin, DS Gibson… - Osteoarthritis and …, 2018 - Elsevier
Osteoarthritis (OA) was previously thought of as 'wear and tear'as humans age, however
there is increasing evidence to support an inflammatory theory. The nucleotide-binding and …

Beyond mechanical loading: The metabolic contribution of obesity in osteoarthritis unveils novel therapeutic targets

BH Sobieh, HO El-Mesallamy, DH Kassem - Heliyon, 2023 - cell.com
Osteoarthritis (OA) is a prevalent progressive disease that frequently coexists with obesity.
For several decades, OA was thought to be the result of ageing and mechanical stress on …

The effect of intra-articular injection of autologous microfragmented fat tissue on proteoglycan synthesis in patients with knee osteoarthritis

D Hudetz, I Borić, E Rod, Ž Jeleč, A Radić, T Vrdoljak… - Genes, 2017 - mdpi.com
Osteoarthritis (OA) is one of the leading musculoskeletal disorders in the adult population. It
is associated with cartilage damage triggered by the deterioration of the extracellular matrix …

Past, present, and future of cartilage restoration: from localized defect to arthritis

DH Lee, SJ Kim, SA Kim, G Ju - Knee Surgery & Related Research, 2022 - Springer
Background Osteoarthritis, one of the most common joint diseases, is characterized by the
loss of joint function due to articular cartilage destruction. Herein, we review current and …

Identification and development of a novel 5-gene diagnostic model based on immune infiltration analysis of osteoarthritis

YG Han, J Wu, ZY Gong, YQ Zhou, HB Li… - Journal of translational …, 2021 - Springer
Background Osteoarthritis (OA), which is due to the progressive loss and degeneration of
articular cartilage, is the leading cause of disability worldwide. Therefore, it is of great …

Cartilage acidic protein 1 in plasma associates with prevalent osteoarthritis and predicts future risk as well as progression to joint replacements: results from the UK …

U Styrkarsdottir, SH Lund, G Thorleifsson… - Arthritis & …, 2023 - Wiley Online Library
Objective The level of cartilage acidic protein 1 (CRTAC1) in plasma was recently
discovered to be associated with osteoarthritis (OA) risk and progression to joint …