[HTML][HTML] Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities
Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …
safe and effective treatments are available. However, new approaches to symptom …
[HTML][HTML] Criteria for psychosis in major and mild neurocognitive disorders: International Psychogeriatric Association (IPA) consensus clinical and research definition
J Cummings, LC Pinto, M Cruz, CE Fischer… - The American journal of …, 2020 - Elsevier
Psychosis is common among individuals with neurocognitive disorders, is difficult to
manage, and causes considerable burden and stress to patients and caregivers …
manage, and causes considerable burden and stress to patients and caregivers …
[HTML][HTML] Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank
In just over a decade, advances in genome-wide association studies (GWAS) have offered
an approach to stratify individuals based on genetic risk for disease. Using recent …
an approach to stratify individuals based on genetic risk for disease. Using recent …
[HTML][HTML] Repurposing of anti-diabetic agents as a new opportunity to alleviate cognitive impairment in neurodegenerative and neuropsychiatric disorders
Cognitive impairment is a shared abnormality between type 2 diabetes mellitus (T2DM) and
many neurodegenerative and neuropsychiatric disorders, such as Alzheimer's disease (AD) …
many neurodegenerative and neuropsychiatric disorders, such as Alzheimer's disease (AD) …
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
MAA DeMichele-Sweet, L Klei, B Creese… - Molecular …, 2021 - nature.com
Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent
in Alzheimer disease (AD with psychosis, AD+ P). AD+ P affects~ 50% of individuals with …
in Alzheimer disease (AD with psychosis, AD+ P). AD+ P affects~ 50% of individuals with …
Revisiting criteria for psychosis in Alzheimer's disease and related dementias: toward better phenotypic classification and biomarker research
Background: Psychotic symptoms are common in Alzheimer's disease (AD) and related
neurodegenerative disorders and are associated with more rapid disease progression and …
neurodegenerative disorders and are associated with more rapid disease progression and …
[HTML][HTML] Polygenic risk and pleiotropy in neurodegenerative diseases
E Bellou, J Stevenson-Hoare, V Escott-Price - Neurobiology of Disease, 2020 - Elsevier
In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases,
focusing on Alzheimer's disease (AD). We summarize the various techniques developed to …
focusing on Alzheimer's disease (AD). We summarize the various techniques developed to …
[HTML][HTML] Polygenic score models for Alzheimer's disease: from research to clinical applications
The high prevalence of Alzheimer's disease (AD) among the elderly population and its lack
of effective treatments make this disease a critical threat to human health. Recent …
of effective treatments make this disease a critical threat to human health. Recent …
[HTML][HTML] Comparative analysis of default mode networks in major psychiatric disorders using resting-state EEG
Default mode network (DMN) is a set of functional brain structures coherently activated when
individuals are in resting-state. In this study, we constructed multi-frequency band resting …
individuals are in resting-state. In this study, we constructed multi-frequency band resting …
[HTML][HTML] scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks
Understanding cell-type-specific gene regulatory mechanisms from genetic variants to
diseases remains challenging. To address this, we developed a computational pipeline …
diseases remains challenging. To address this, we developed a computational pipeline …