[PDF][PDF] Protein tyrosine phosphorylation in T cell signaling

T Mustelin, RT Abraham, CE Rudd, A Alonso, JJ Merlo - Front Biosci, 2002 - academia.edu
Introduction 2.1. Inositol phospholipid hydrolysis and calcium mobilization 2.2. TCR-induced
tyrosine phosphorylation 3. Src-related kinases in T cells 3.1. Lck-a co-receptor associated …

The infrequency of transmission of herpesviruses between humans and animals; postulation of an unrecognised protective host mechanism

GRB Skinner, A Ahmad, JA Davies - … immunology, microbiology and …, 2001 - Elsevier
The infrequency of natural transmission of herpesviruses between humans and animals is
surprising as there is extensive contact between humans and non-human species with …

Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts

EA Feshchenko, SK Shore, AY Tsygankov - Oncogene, 1999 - nature.com
The protooncogenic protein c-Cbl becomes tyrosine phosphorylated in normal cells in
response to a variety of external stimuli, as well as in cells transformed by oncogenic protein …

Molecular mechanisms of the effect of herpesvirus saimiri protein StpC on the signaling pathway leading to NF-κB activation

EM Sorokina, JJ Merlo, AY Tsygankov - Journal of Biological Chemistry, 2004 - ASBMB
Herpesvirus saimiri (Saimiriine herpesvirus-2) causes lethal T lymphoproliferative diseases
in the susceptible species and transforms T lymphocytes to continuous growth in vitro. H …

[HTML][HTML] Tip, an Lck-interacting protein of Herpesvirus saimiri, causes Fas-and Lck-dependent apoptosis of T lymphocytes

MG Hasham, AY Tsygankov - Virology, 2004 - Elsevier
Saimiriine herpesvirus-2 (Herpesvirus saimiri) transforms T lymphocytes, including human,
to continuous growth in vitro. H. saimiri-induced transformation is becoming an important …

Herpesvirus saimiri oncoproteins Tip and StpC synergistically stimulate NF-κB activity and interleukin-2 gene expression

JJ Merlo, AY Tsygankov - Virology, 2001 - Elsevier
Saimiriine herpesvirus 2 (Herpesvirus saimiri) is capable of inducing lethal T-cell
lymphoproliferative diseases in primates and of immortalizing human T lymphocytes in vitro …

c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases

AM Teckchandani, EA Feshchenko, AY Tsygankov - Oncogene, 2001 - nature.com
The protooncogenic protein c-Cbl has been shown to act as a multivalent adaptor and a
negative regulator of protein tyrosine kinase-mediated signaling. Recent studies have …

c-Cbl regulates migration of v-Abl-transformed NIH 3T3 fibroblasts via Rac1

AM Teckchandani, TS Panetti, AY Tsygankov - Experimental cell research, 2005 - Elsevier
Cellular events like cell adhesion and migration involve complex rearrangements of the
actin cytoskeleton. We have previously shown that the multidomain adaptor protein c-Cbl …

Cell transformation by Herpesvirus saimiri

AY Tsygankov - Journal of cellular physiology, 2005 - Wiley Online Library
Abstract Herpesvirus saimiri (Saimiriine herpesvirus‐2), a γ2‐herpesvirus (rhadinovirus) of
non‐human primates, causes T‐lymphoproliferative diseases in susceptible organisms and …

Altered replication of human immunodeficiency virus type 1 (HIV-1) in T cell lines retrovirally transduced to express Herpesvirus saimiri proteins StpC and/or Tip

EE Henderson, AY Tsygankov, JJ Merlo, G Romano… - Virology, 1999 - Elsevier
Human peripheral blood T lymphocytes are transformed in vitro to continuous proliferation
by Herpesvirus saimiri subgroup C strains. It has been previously shown that H. saimiri …