Calcium research, since its pivotal discovery in the early 1800s through the heating of
limestone, has led to the identification of its multi-functional roles. These include its functions …

Arrhythmogenic cardiomyopathy affects significant number of patients worldwide and is
characterized by life-threatening ventricular arrhythmias and sudden cardiac death …

Diabetic cardiomyopathy is defined as the myocardial dysfunction that suffers patients with
diabetes mellitus (DM) in the absence of hypertension and structural heart diseases such as …

A decrease in skeletal muscle contractile activity or its complete cessation (muscle
unloading or disuse) leads to muscle fibers' atrophy and to alterations in muscle …

The contraction of cardiac muscle underlying the pumping action of the heart is mediated by
the process of excitation-contraction coupling (ECC). While triggered by Ca2+ entry across …

Inherited cardiomyopathy caused by the p.(Arg14del) pathogenic variant of the
phospholamban (PLN) gene is characterized by intracardiomyocyte PLN aggregation and …

The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically
distinct and partially independent calcium (Ca2+) signaling microdomain, with its own Ca2+ …

Oxidative stress could be a possible mechanism and a therapeutic target of atrial fibrillation
(AF). However, the effects of the xanthine oxidase (XO) inhibition for AF remain to be fully …

Aims Phospholamban (PLB) stoichiometrically regulates the cardiac Ca 2+ pump
(SERCA2a) in the sarcoplasmic reticulum (SR); but in the nuclear envelope (NE) of …

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and recent
epidemiological studies suggested type 2 diabetes mellitus (T2DM) is an independent risk …