Alcohol use disorder (AUD) is a complex brain disorder with an array of persistent
behavioral and neurochemical manifestations. Both genetic and environmental factors are …

The association of the histone deacetylase (HDAC) inhibitor valproate (VPA) with atypical
antipsychotics has become a frequent treatment strategy for schizophrenia and bipolar …

Since the publication of our previous Perspective dealing with polyamine drug discovery, 1
the field has undergone numerous changes. Most prominent among these changes, from a …

Relying on an immune system comes with a high energetic cost for plants. Defense
responses in these organisms are therefore highly regulated and fine-tuned, permitting them …

Epigenetic aberrations and cancer | Molecular Cancer Skip to main content SpringerLink
Account Menu Find a journal Publish with us Track your research Search Cart 1.Home 2.Molecular …

General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of
the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase …

Epigenetics is the branch of molecular biology that studies modifications able to change
gene expression without altering the DNA sequence. Epigenetic modulations include DNA …

Epithelial–mesenchymal transition (EMT) is vital for morphogenesis during embryonic
development and is also critical for the conversion of early stage tumors into invasive …

Purpose: Antineoplastic drugs belonging to platinum or taxane families are severely
neurotoxic, inducing the onset of disabling peripheral neuropathies with different clinical …

We have previously described novel histone acetyltransferase (HAT) inhibitors that block
neuroblastoma cell growth in vitro. Here we show that two selected pyridoisothiazolone HAT …