Simple Summary Given the rising mortality rate caused by GBM, current therapies do not
appear to be effective in counteracting tumor progression. The role of adenosine and its …

Food addiction is linked to obesity and eating disorders and is characterized by a loss of
behavioral control and compulsive food intake. Here, using a food addiction mouse model …

Epilepsy and autism spectrum disorder (ASD) are highly mutually comorbid, suggesting
potential overlaps in genetic etiology, pathophysiology, and neurodevelopmental …

Increased ATP release and its extracellular catabolism through CD73 (ecto-5′-
nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in …

Adenosine receptors mainly control synaptic function, and excessive activation of adenosine
receptors may worsen the onset of many neurological disorders. Accordingly, the regular …

Many people consume coffee to attenuate increased sleepiness and impaired vigilance and
attention due to insufficient sleep. We investigated in genetically caffeine sensitive men and …

Aims Cerebral ischemic stroke leads to mitochondrial alterations which are key factors for
initiation of various cascades resulting in neuronal damage. Dopamine D2 receptor (D2R) …

Single-cell transcriptomics are powerful tools to define neuronal cell types based on co-
expressed gene clusters. Limited RNA input in these technologies necessarily compromises …

Adenosinergic system dysfunction is implicated in the pathophysiology of multiple
neuropsychiatric disorders including mania and bipolar diseases. The established …

The cost-benefit decision-making (CBDM) is critical to normal human activity and a
diminished willingness to expend effort to obtain rewards is a prevalent/noted characteristic …