In recent decades, traditional eating habits have been replaced by a more globalized diet,
rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary …

Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …

Conventional transnasal brain-targeted drug delivery strategies are limited by nasal cilia
clearance and the nasal mucosal barrier. To address this challenge, we designed dissolving …

Abstract Coronavirus disease 2019 (COVID-19) affects numerous systems of the body
during the illness, and there have been long-lasting effects. BDNF plays an important role in …

Stroke is a common cerebrovascular disease with high morbidity, mortality, and disability
worldwide. Post-stroke dysfunction is related to the death of neurons and impairment of …

Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, and
recent studies in the hippocampus found that LTP was impaired in aged animals. Previous …

A decline in microglia in the dentate gyrus of the hippocampus has recently been described
as an important mechanism for the progression of depression. Reversal of this decline by …

Millions of residents in areas with high-fluoride drinking water supply ingest excessive levels
of fluoride for long periods. This study investigated the mechanisms and impacts of lifelong …

An increasing body of evidence has become available to reveal the synaptic and functional
integration of glioma into the brain network, facilitating tumor progression. The novel …

Synaptic plasticity is the capacity of synaptic transmission between neurons to be
strengthened or weakened. There are many signal molecules accumulated in the …