[HTML][HTML] Clinico-pathogenic similarities and differences between infection-related glomerulonephritis and C3 glomerulopathy
Y Wada, M Kamata, R Miyasaka, T Abe… - International Journal of …, 2023 - mdpi.com
Recently, the comprehensive concept of “infection-related glomerulonephritis (IRGN)” has
replaced that of postinfectious glomerulonephritis (PIGN) because of the diverse infection …
replaced that of postinfectious glomerulonephritis (PIGN) because of the diverse infection …
[HTML][HTML] Treatment of C3 glomerulopathy in adult kidney transplant recipients: a systematic review
Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative
complement pathway dysregulation, is associated with a high rate of recurrence and graft …
complement pathway dysregulation, is associated with a high rate of recurrence and graft …
[HTML][HTML] Alternative complement pathway inhibition with iptacopan for the treatment of C3 glomerulopathy-study design of the APPEAR-C3G trial
AS Bomback, D Kavanagh, M Vivarelli, M Meier… - Kidney International …, 2022 - Elsevier
Introduction Complement 3 glomerulopathy (C3G) is a rare kidney disease characterized by
dysregulation of the alternative pathway (AP) of the complement system. About 50% of …
dysregulation of the alternative pathway (AP) of the complement system. About 50% of …
[HTML][HTML] Efficacy and safety of iptacopan in patients with C3 glomerulopathy
E Wong, C Nester, T Cavero, A Karras… - Kidney international …, 2023 - Elsevier
Introduction Complement 3 glomerulopathy (C3G) is a rare inflammatory kidney disease
mediated by dysregulation of the alternative complement pathway. No targeted therapy …
mediated by dysregulation of the alternative complement pathway. No targeted therapy …
[HTML][HTML] Clinical safety and efficacy of pegcetacoplan in a phase 2 study of patients with C3 glomerulopathy and other complement-mediated glomerular diseases
BP Dixon, LA Greenbaum, L Huang, S Rajan… - Kidney International …, 2023 - Elsevier
Introduction Dysregulated complement activation is likely the primary driver of disease in C3
glomerulopathy (C3G) and contributes to other complement-mediated diseases, including …
glomerulopathy (C3G) and contributes to other complement-mediated diseases, including …
Longitudinal change in proteinuria and kidney outcomes in C3 glomerulopathy
F Caravaca-Fontán, M Díaz-Encarnación… - Nephrology Dialysis …, 2022 - academic.oup.com
Introduction The association between a change in proteinuria over time and its impact on
kidney prognosis has not been analysed in complement component 3 (C3) glomerulopathy …
kidney prognosis has not been analysed in complement component 3 (C3) glomerulopathy …
[HTML][HTML] Clinicopathologic implications of complement genetic variants in kidney transplantation
Z Ren, SJ Perkins, L Love-Gregory, JP Atkinson… - Frontiers in …, 2021 - frontiersin.org
Genetic testing has uncovered rare variants in complement proteins associated with
thrombotic microangiopathy (TMA) and C3 glomerulopathy (C3G). Approximately 50% are …
thrombotic microangiopathy (TMA) and C3 glomerulopathy (C3G). Approximately 50% are …
[HTML][HTML] Regulation of complement activation by heme oxygenase-1 (HO-1) in kidney injury
MG Detsika, EA Lianos - Antioxidants, 2021 - mdpi.com
Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic
properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves …
properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves …
C3 glomerulopathy associated with monoclonal gammopathy: impact of chronic histologic lesions and beneficial effects of clone-targeted therapies
F Caravaca-Fontán, L Lucientes, N Serra… - Nephrology Dialysis …, 2022 - academic.oup.com
Background C3 glomerulopathy associated with monoclonal gammopathy (C3G-MIg) is a
rare entity. Herein we analysed the clinical and histologic features of a cohort of C3G-MIg …
rare entity. Herein we analysed the clinical and histologic features of a cohort of C3G-MIg …
[HTML][HTML] Deciphering the Genetic Code of Autoimmune Kidney Diseases
SUS Huang, O Kulatunge, KM O'Sullivan - Genes, 2023 - mdpi.com
Autoimmune kidney diseases occur due to the loss of tolerance to self-antigens, resulting in
inflammation and pathological damage to the kidneys. This review focuses on the known …
inflammation and pathological damage to the kidneys. This review focuses on the known …